Fig. 5
a Model of lymphomagenesis and treatment response. C57BL/6 mice were tail vein injected with 106 Tsc2+/−Eμ-Myc lymphoma cells. Two days later, animals were randomly grouped and treatments started. b Kaplan-Meier plot showing overall survival of mice bearing Tsc2+/−Eμ-Myc tumors following treatment with vehicle (Veh, solid black line; n = 5), or obatoclax (Obx, solid red line; n = 5). c Model of lymphomagenesis and treatment response. C57BL/6 mice were tail vein injected with 106 Eμ-Myc/(myr)Akt lymphoma cells. Upon appearance of tumors, animals were randomly grouped and treatments started. d Kaplan-Meier plot showing tumor free survival of mice bearing Eμ-Myc/(myr)Akt tumors following treatment with doxorubicin (Dxr, solid black line; n = 4), obatoclax (Obx, solid red line; n = 5), or obatoclax and doxorubicin (Obx + Dxr, dashed red line; n = 5)