Table 3 Eight independent datasets from ArrayExpress and GEO website. Gene expression microarray datasets were normalized using RMA with package “affy”. Student t-test was performed for examining the differential expression of C1orf63 between cases and controls of several cancers
Cancer | Accession number | Array | Sample size | Log-2 mRNA signal intensity (mean ± SD*) | P | ||
|---|---|---|---|---|---|---|---|
Control | Case | Control | Case | ||||
Breast cancer | GSE42568 | HG-U133_Plus_2 | 17 | 104 | 6.36 ± 0.54 | 7.57 ± 0.78 | <0.001 |
GSE15852 | HG-U133A | 43 | 43 | 9.49 ± 0.18 | 9.74 ± 0.21 | <0.001 | |
Lung cancer | E-MEXP-231 | HG-U133A | 9 | 49 | 7.83 ± 0.40 | 8.62 ± 0.65 | 0.001 |
GSE19804 | HG-U133_Plus_2 | 60 | 60 | 8.13 ± 0.73 | 8.41 ± 0.78 | 0.046 | |
Prostate cancer | GSE6956 | HG-U133A_2 | 20 | 69 | 9.44 ± 1.11 | 10.46 ± 0.36 | <0.001 |
GSE6919 | HG_U95Av2 | 81 | 65 | 4.62 ± 0.24 | 4.67 ± 0.23 | 0.040 | |
Hepatocellular carcinoma | GSE14323 | HG-U133A_2 | 19 | 38 | 6.95 ± 0.46 | 7.82 ± 0.53 | <0.001 |
GSE6764 | HG-U133_Plus_2 | 10 | 62 | 7.57 ± 0.81 | 8.45 ± 0.54 | <0.001 | |