XAB2 tagSNPs contribute to non-small cell lung cancer susceptibility in Chinese population

Pei, Na; Cao, Lei; Liu, Yingwen; Wu, Jing; Song, Qinqin; Zhang, Zhi; Yuan, Juxiang; Zhang, Xuemei

doi:10.1186/s12885-015-1567-4

BMC Cancer

Table 4 Association of XAB2 tagSNPs with NSCLC risk stratified by selected variables

From: XAB2 tagSNPs contribute to non-small cell lung cancer susceptibility in Chinese population

Genetic Variant	Variable	Genotypes (Cases/Controls)		Dominant model (AB + BB)/AA^bOR (95 % CI)^a	P value
		AA^b	AB + BB^b
rs4134816	Sex
T > C	Male	314/301	10/27	0.39 (0.18–0.82)	0.013
	Female	136/128	10/14	0.68 (0.29–1.59)	0.370
	Age
	≤60	251/254	10/29	0.35 (0.17–0.74)	0.006
	>60	199/175	10/12	0.98 (0.40–2.39)	0.970
	Smoking status
	Non-smoker	252/256	13/24	0.51 (0.26–1.03)	0.060
	Ever-smoker	198/173	7/16	0.47 (0.19–1.20)	0.113
rs4134819	Sex
A > G	Male	80/90	244/238	1.10 (0.77–1.58)	0.591
	Female	46/32	100/110	0.64 (0.38–1.09)	0.098
	Age
	≤60	76/77	185/206	0.91 (0.63–1.33)	0.638
	>60	50/45	159/142	0.92 (0.57–1.48)	0.726
	Smoking status
	Non-smoker	82/75	183/206	0.81 (0.56–1.17)	0.252
	Ever-smoker	44/47	161/142	1.13 (0.70–1.82)	0.628
rs794083	Sex
C > G	Male	169/159	155/169	0.88 (0.64–1.20)	0.415
	Female	80/62	66/80	0.66 (0.41–1.05)	0.081
	Age
	≤60	139/140	122/143	0.90 (0.64–1.27)	0.546
	>60	110/81	99/106	0.71 (0.47–1.07)	0.098
	Smoking status
	Non-smoker	144/139	121/142	0.81 (0.58–1.14)	0.226
	Ever-smoker	105/82	100/107	0.74 (0.49–1.11)	0.141
rs4134860	Sex
T > C	Male	227/237	97/91	1.14 (0.80–1.61)	0.470
	Female	105/104	41/38	1.11 (0.66–1.87)	0.702
	Age
	≤60	186/211	75/72	1.24 (0.84–1.82)	0.275
	>60	146/130	63/57	0.97 (0.63–1.51)	0.906
	Smoking status
	Non-smoker	190/207	75/74	1.10 (0.76–1.61)	0.608
	Ever-smoker	142/134	63/55	1.05 (0.67–1.63)	0.841
rs794078	Sex
G > A	Male	256/256	68/72	0.92 (0.63–1.35)	0.673
	Female	118/109	28/33	0.79 (0.45–1.40)	0.426
	Age
	≤60	208/226	53/57	1.04 (0.68–1.58)	0.872
	>60	166/139	43/48	0.74 (0.46–1.20)	0.226
	Smoking status
	Non-smoker	211/225	54/56	1.02 (0.67–1.55)	0.930
	Ever-smoker	163/140	42/49	0.73 (0.45–1.18)	0.202

^aData were calculated by unconditional logistic regression and adjusted for gender, age (categories), and smoking status, where it was appropriate
^bA stands for Major allele and B stands for Minor allele for each SNP

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ISSN: 1471-2407

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