Skip to main content

Table 4 Association of XAB2 tagSNPs with NSCLC risk stratified by selected variables

From: XAB2 tagSNPs contribute to non-small cell lung cancer susceptibility in Chinese population

Genetic Variant Variable Genotypes (Cases/Controls) Dominant model (AB + BB)/AAbOR (95 % CI)a P value
   AAb AB + BBb   
rs4134816 Sex     
  T > C  Male 314/301 10/27 0.39 (0.18–0.82) 0.013
   Female 136/128 10/14 0.68 (0.29–1.59) 0.370
  Age     
   ≤60 251/254 10/29 0.35 (0.17–0.74) 0.006
   >60 199/175 10/12 0.98 (0.40–2.39) 0.970
  Smoking status     
   Non-smoker 252/256 13/24 0.51 (0.26–1.03) 0.060
   Ever-smoker 198/173 7/16 0.47 (0.19–1.20) 0.113
rs4134819 Sex     
  A > G  Male 80/90 244/238 1.10 (0.77–1.58) 0.591
   Female 46/32 100/110 0.64 (0.38–1.09) 0.098
  Age     
   ≤60 76/77 185/206 0.91 (0.63–1.33) 0.638
   >60 50/45 159/142 0.92 (0.57–1.48) 0.726
  Smoking status     
   Non-smoker 82/75 183/206 0.81 (0.56–1.17) 0.252
   Ever-smoker 44/47 161/142 1.13 (0.70–1.82) 0.628
rs794083 Sex     
  C > G  Male 169/159 155/169 0.88 (0.64–1.20) 0.415
   Female 80/62 66/80 0.66 (0.41–1.05) 0.081
  Age     
   ≤60 139/140 122/143 0.90 (0.64–1.27) 0.546
   >60 110/81 99/106 0.71 (0.47–1.07) 0.098
  Smoking status     
   Non-smoker 144/139 121/142 0.81 (0.58–1.14) 0.226
   Ever-smoker 105/82 100/107 0.74 (0.49–1.11) 0.141
rs4134860 Sex     
  T > C  Male 227/237 97/91 1.14 (0.80–1.61) 0.470
   Female 105/104 41/38 1.11 (0.66–1.87) 0.702
  Age     
   ≤60 186/211 75/72 1.24 (0.84–1.82) 0.275
   >60 146/130 63/57 0.97 (0.63–1.51) 0.906
  Smoking status     
   Non-smoker 190/207 75/74 1.10 (0.76–1.61) 0.608
   Ever-smoker 142/134 63/55 1.05 (0.67–1.63) 0.841
rs794078 Sex     
  G > A  Male 256/256 68/72 0.92 (0.63–1.35) 0.673
   Female 118/109 28/33 0.79 (0.45–1.40) 0.426
  Age     
   ≤60 208/226 53/57 1.04 (0.68–1.58) 0.872
   >60 166/139 43/48 0.74 (0.46–1.20) 0.226
  Smoking status     
   Non-smoker 211/225 54/56 1.02 (0.67–1.55) 0.930
   Ever-smoker 163/140 42/49 0.73 (0.45–1.18) 0.202
  1. aData were calculated by unconditional logistic regression and adjusted for gender, age (categories), and smoking status, where it was appropriate
  2. bA stands for Major allele and B stands for Minor allele for each SNP