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Table 2 Association between pathologic responsiveness of breast cancer to NAC and receptor status

From: Texture analysis on MR images helps predicting non-response to NAC in breast cancer

Pathologic response NR CR PR PR + CR p-valuea
BI-RADS      
 Mass 12 (31 %)    27 (69 %) 0.51
 non Mass 7 (23 %)    23 (77 %) 0.51
Biological markers      
 ER positivity 15 (29 %) 9 (17 %) 28 (54 %) 37 (71 %) 0.70
 PgR positivity 14 (33 %) 4 (10 %) 24 (57 %) 28 (67 %) 0.19
 Ki67 > 14 % 11 (21 %) 11 (21 %) 30 (58 %) 41 (79 %) 0.05
 HER2 positivity 4 (15 %) 8 (31 %) 14 (54 %) 22 (85 %) 0.09
Subtypes      
 Luminal A 8 (62 %) 0 5 (38 %) 5 (38 %) 0.005
 Luminal B/ HER2 – 4 (16 %) 5 (20 %) 16 (64 %) 21 (84 %) 0.11
 Luminal B/HER2 + 3 (20 %) 4 (27 %) 8 (53 %) 12 (80 %) 0.49
 Non-luminal/HER2 + 1 (10 %) 4 (40 %) 5 (50 %) 9 (90 %) 0.20
 Triple-negative cancer rate 3 (50 %) 1 (17 %) 2 (33 %) 3 (50 %) 0.25
Histological grade      
 IDC 2 5 (20 %) 3 (12 %) 17 (68 %) 20 (80 %) 0.31
 IDC 3 14 (32 %) 11 (25 %) 19 (43 %) 30 (68 %) 0.31
  1. The number and proportions of NR, CR, PR and PR + CR patients with a given feature within all patients having this feature are given. The statistical significance of the relationship between response (NR or PR + CR) and features is then assessed (p-valuea). If a p-value < 0.05 is observed for a given feature, then we can conclude that patients’ response is associated to that feature. If a p-value > 0.05 is observed, then the null hypothesis that there is no association, cannot be rejected. Subtype Luminal A is the only feature showing a significant association with response
  2. BI-RADS breast imaging-reporting and data system, NR non response, CR complete response, PR partial response, ER estrogen receptor, PgR progesterone receptor, Ki67 cellular marker for proliferation based on monoclonal antibody Ki-67, HER2 human epidermal growth factor receptor 2, HR hormone receptor, IDC invasive ductal carcinoma
  3. aSignificance of the association between response (NR or PR + CR) and features (Fisher’s exact test)