The prognostic value of SUMO1/Sentrin specific peptidase 1 (SENP1) in prostate cancer is limited to ERG-fusion positive tumors lacking PTEN deletion

Table 4 Multivariate analysis including SENP1 expression in a) all cancers, b) ERG-negative, c) ERG-positive cancers and d) ERG-positive cancers lacking PTEN deletion

a)
Scenario	n analyzable	p -value
Scenario	n analyzable	Preoperative PSA-Level	pT Stage	cT Stage	Gleason grade prostatectomy	Gleason grade biopsy	N-Stage	R-Status	SENP1 Expression
1	5,273	<0.0001	<0.0001	-	<0.0001	-	0.0001	0.0008	0.9255
2	8,392	<0.0001	<0.0001	-	<0.0001	-	-	<0.0001	0.9136
3	8,268	<0.0001	-	<0.0001	<0.0001	-	-	-	0.6842
4	8,155	<0.0001	-	<0.0001	-	<0.0001	-	-	0.0227
b)
Scenario	n analyzable	p -value
Scenario	n analyzable	Preoperative PSA-Level	pT Stage	cT Stage	Gleason-grade prostatectomy	Gleason grade biopsy	N-Stage	R-Status	SENP1 Expression
1	2,681	0.0004	<0.0001	-	<0.0001	-	0.0006	0.1375	0.1487
2	4,179	<0.0001	<0.0001	-	<0.0001	-	-	0.0022	0.1962
3	4,145	<0.0001	-	<0.0001	<0.0001	-	-	-	0.3180
4	4,091	<0.0001	-	<0.0001	-	<0.0001	-	-	0.3539
c)
Scenario	n analyzable	p -value
Scenario	n analyzable	preoperative PSA-Level	pT Stage	cT Stage	Gleason-grade prostatectomy	Gleason grade biopsy	N-Stage	R-Status	SENP1 Expression
1	2,090	0.0003	<0.0001	-	<0.0001	-	0.0073	0.0065	0.4108
2	3,279	<0.0001	<0.0001	-	<0.0001	-	-	<0.0001	0.4351
3	3,203	<0.0001	-	<0.0001	<0.0001	-	-	-	0.3231
4	3,156	<0.0001	-	<0.0001	-	<0.0001	-	-	0.0143
d)
Scenario	n analyzable	p -value
Scenario	n analyzable	preoperative PSA-Level	pT Stage	cT Stage	Gleason-grade prostatectomy	Gleason grade biopsy	N-Stage	R-Status	SENP1 Expression
1	872	0.0015	<0.0001	-	<0.0001	-	0.0007	0.0958	0.1174
2	1,495	0.0012	<0.0001	-	<0.0001	-	-	0.0017	0.0157
3	1,463	<0.0001	-	0.0197	<0.0001	-	-	-	0.0057
4	1,444	<0.0001	-	0.0354	-	<0.0001	-	-	0.0005

ISSN: 1471-2407