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Table 2 Univariable and multivariable analysis of overall and cancer-specific survival

From: Population-based SEER trend analysis of overall and cancer-specific survival in 5138 patients with gastrointestinal stromal tumor

   Overall survival Cancer-specific survival
Covariates   Unadjusted a Cox regression, full model b Unadjusted a Cox regression, full model b
   HR (95 % CI) p c) HR (95 % CI) p c) HR (95 % CI) p c) HR (95 % CI) p c)
Location Stomach Reference <0.001 Reference 0.002 Reference <0.001 Reference <0.001
  Small intestine 0.87 (0.78–0.97)   0.98 (0.87–1.10)   0.90 (0.78–1.03)   0.96 (0.83–1.11)  
  Other 1.31 (1.13–1.53)   1.30 (1.12–1.52)   1.54 (1.30–1.84)   1.46 (1.22–1.74)  
Size <5 cm Reference <0.001 Reference <0.001 Reference <0.001 Reference <0.001
  5 cm–9.9 cm 1.13 (0.97–1.32)   1.04 (0.89–1.21)   1.52 (1.23–1.89)   1.38 (1.12–1.72)  
  10 cm+ 1.94 (1.68–2.25)   1.63 (1.40–1.89)   3.15 (2.58–3.85)   2.52 (2.05–3.08)  
  Unknown 2.36 (2.01–2.78)   1.49 (1.25–1.78)   3.72 (2.99–4.62)   2.00 (1.58–2.52)  
Metastatic disease M0 Reference <0.001 Reference <0.001 Reference <0.001 Reference <0.001
  M1 2.84 (2.56–3.16)   2.03 (1.80–2.28)   3.69 (3.26–4.17)   2.42 (2.11–2.78)  
N stage N− Reference <0.001 Reference 0.001 Reference <0.001 Reference 0.001
  N+ 2.28 (1.89–2.74)   1.47 (1.21–1.79)   2.73 (2.20–3.38)   1.55 (1.24–1.93)  
  NX 1.83 (1.63–2.05)   1.09 (0.96–1.24)   2.12 (1.85–2.42)   1.16 (1.00–1.36)  
Surgery of the No surgery primary Reference <0.001 Reference <0.001 Reference <0.001 Reference <0.001
primary Surgery primary 0.33 (0.29–0.36)   0.49 (0.43–0.56)   0.27 (0.24–0.31)   0.44 (0.38–0.52)  
  Unknown 0.87 (0.36–2.09)   1.36 (0.56–3.31)   0.90 (0.34–2.42)   1.36 (0.50–3.67)  
Year 1998 to 2002 Reference <0.001 Reference <0.001 Reference <0.001 Reference <0.001
  2003 to 2005 0.79 (0.70–0.90)   0.76 (0.67–0.86)   0.76 (0.66–0.88)   0.73 (0.63–0.85)  
  2006 to 2008 0.67 (0.58–0.77)   0.61 (0.53–0.71)   0.66 (0.56–0.79)   0.63 (0.53–0.75)  
  2009 to 2011 0.63 (0.53–0.76)   0.62 (0.51–0.75)   0.55 (0.44–0.69)   0.55 (0.44–0.70)  
Gender Male Reference <0.001 Reference <0.001 Reference 0.001 Reference <0.001
  Female 0.79 (0.72–0.88)   0.70 (0.63–0.78)   0.81 (0.72–0.92)   0.77 (0.68–0.88)  
Age <50 Reference <0.001 Reference <0.001 Reference <0.001 Reference <0.001
  50–64 1.27 (1.08–1.50)   1.40 (1.19–1.66)   1.00 (0.83–1.19)   1.11 (0.92–1.33)  
  65–79 2.25 (1.92–2.63)   2.64 (2.25–3.10)   1.54 (1.29–1.83)   1.83 (1.53–2.18)  
  80+ 4.92 (4.15–5.83)   5.64 (4.70–6.76)   2.91 (2.39–3.55)   3.19 (2.58–3.95)  
Ethnicity Caucasian Reference 0.001 Reference 0.002 Reference 0.013 Reference 0.058
  African-American 1.19 (1.06–1.35)   1.22 (1.07–1.39)   1.15 (0.99–1.34)   1.08 (0.92–1.27)  
  Other/Unknown 0.86 (0.74–1.01)   0.88 (0.76–1.03)   0.82 (0.68–1.00)   0.83 (0.68–1.00)  
Marital status Married Reference <0.001 Reference <0.001 Reference <0.001 Reference <0.001
  Single 1.18 (1.03–1.36)   1.38 (1.19–1.59)   1.29 (1.10–1.53)   1.40 (1.18–1.66)  
  Other/Unknown 1.48 (1.32–1.66)   1.19 (1.05–1.35)   1.44 (1.25–1.65)   1.22 (1.05–1.42)  
  1. Hazard ratios (HR) with 95 % confidence intervals
  2. aunivariate Cox regression analysis
  3. bmultivariable Cox regression analysis full model including all covariates depicted in the table rows on the left
  4. clikelihood ratio tests