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Table 5 Univariate and multivariate Cox analysis of predictive factors for progression-free survival in 57 SOEC patients treated with taxane-based chemotherapy

From: Overexpression of Class III β-tubulin, Sox2, and nuclear Survivin is predictive of taxane resistance in patients with stage III ovarian epithelial cancer

Variables

Univariate

Multivariate

HR (95 % CI)

χ 2

P

HR (95 % CI)

χ 2

P

Age (years)

0.669 (0.282-1.586)

0.835

0.361

-

-

-

    <65

      

    ≥65

      

Histotype

1.458 (0.720-2.950)

1.099

0.295

-

-

-

    Serous

      

    Others

      

Grade

1.244 (0.759-2.041)

0.750

0.386

-

-

-

    G1-2

      

    G3

      

Ascites (mL)

0.990 (0.552-1.774)

0.001

0.973

-

-

-

    <1000

      

    >1000

      

Residual tumor (cm)

3.333 (1.650-6.732)

11.266

0.001*

3.050 (1.499-6.205)

9.471

0.002*

    <1

      

    ≥1

      

Class III β-tubulin

1.870 (1.022-3.423)

4.121

0.042*

1.915 (1.036-3.538)

4.301

0.038*

    Positive

      

    Negative

      

Sox2

2.623 (1.273-5.407)

6.829

0.009*

2.100 (1.009-4.373)

3.935

0.047*

    Positive

      

    Negative

      

Nuclear Survivin

1.838 (1.009-3.349)

3.959

0.047*

-

-

-

    Positive

      

    Negative

      

Cytoplasmic Survivin

0.958 (0.495-1.852)

0.016

0.898

-

-

-

    Positive

      

    Negative

      
  1. HR hazard ratios, CI confidence interval
  2. *P < 0.05; only variables with P < 0.10 in the univariate analysis were included in the multivariate model
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BMC Cancer

ISSN: 1471-2407

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