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Table 5 The correlations between the overall survival and various clinicopathological factors in the validation study

From: The prognostic significance of the postoperative prognostic nutritional index in patients with colorectal cancer

  Univariate analysis Multivariate analysis
  Hazard Ratio 95 % CI p-value Hazard Ratio 95 % CI p-value
Age (>70 years) 4.070 1.718–9.646 0.001 0.469 0.095–2.313 0.353
Gender (Female) 1.335 0.578–3.085 0.499    
Location of primary tumor (Rectum) 0.492 0.208–1.160 0.105    
Tumor depth (T4) 1.524 0.668–3.480 0.317 0.625 0.163–2.391 0.492
Histological type (Poorly, Mucinous) 4.230 1.567–11.417 0.004 7.723 1.057–56.416 0.044
The number of lymph node metastases (≥4) 4.356 1.920–9.882 <0.001 5.707 1.279–25.465 0.022
Preoperative CEA (>5 ng/ml) 2.709 1.086–6.757 0.033 4.355 1.090–17.394 0.037
Preoperative CA19-9 (>37 U/ml) 1.740 0.401–7.538 0.459    
Adjuvant chemotherapy (None) 0.399 0.093–1.707 0.215 1.110 0.198–6.230 0.906
The amount of blood lost (>100 ml) 0.794 0.335–1.882 0.600 0.271 0.070–1.050 0.059
Combination of pre and postoperative PNI (<43) 2.019 1.327–3.072 0.001 2.542 1.490–4.337 0.001
  1. CI confidence interval, CEA carcinoembryonic antigen, CA19-9 carbohydrate antigen 19–9, PNI prognostic nutritional index