Fig. 2

The combination of Rap with Dex effectively inhibits the growth of Rap- and Dex-resistant Raji cells in vitro and in vivo. a Raji cells were incubated with Rap (10 nM) and/or Dex (1 μM) for 48 h. The viability of the cells were evaluated with an MTT assay. b Flow cytometric analysis showed the cell size (as seen by FS) after 48 h treatment with 10 nM Rap and/or 1 μM Dex. c Combined treatment significantly inhibited tumor growth in Raji cell xenografts in nude mice (n = 6 per group, age 5 ~ 6 weeks, average-weight 16.9 ~ 17.1 g). All animal procedures were carried out in accordance with ARRIVE guidelines (Additional file 1). *: p < 0.01 versus the control group, Dex group, or Rap group