Table 3 The characteristics of nine patients with no response to R-based treatment (N = 9)
No of patients | Case 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
|---|---|---|---|---|---|---|---|---|---|
Disease | CLL | CLL | CLL | CLL | LPL | MZL | BLPD-U | BLPD-U | BLPD-U |
Age (years old) | 70 | 52 | 46 | 69 | 76 | 64 | 70 | 76 | 82 |
Sex (F/M) | F | F | F | M | M | F | M | M | M |
ECOG score | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 |
β2-MG (mg/ L) | 4.67 | 1.96 | - | 4.2 | 3.78 | 2.08 | 2.63 | 6.93 | - |
LDH (U/L) | 228 | 224 | 1892 | 155 | 221 | 159 | 198 | 232 | - |
Del (13q) | - | - | - | - | - | - | - | - | - |
Del (17p) | - | + | - | - | - | - | a | a | - |
IgH | - | + | + | + | - | - | - | - | - |
Del (ATM) | + | - | - | - | - | - | - | - | - |
Complex karyotype | no | no | yes | no | no | no | yes | no | no |
ZAP70 | - | + | - | - | - | a | a | a | - |
CD38 | - | + | - | + | + | + | - | - | - |
Courses of R-regimens | 2 | 3 | 8 | 2 | 4 | 2 | 2 | 3 | 2 |
Treatment response | SD | PD | SD | SD | SD | PD | SD | SD | SD |
PFS (months) | 4 | 4 | 9 | 25 | 5 | 10 | 3.5 | 8 | 30 |
OS (months) | 6 | 44 | 12 | 30 | 5 | 10 | 3.5 | 10 | 33 |
Outcome | dead | alive | dead | dead | dead | dead | dead | dead | dead |