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Table 6 Host and bacterium variables associated with gastric cancer (n = 213) in comparison with gastritis (n = 174) in patients infected by H. pylori cagA-positive strains

From: STAT3 polymorphism and Helicobacter pylori CagA strains with higher number of EPIYA-C segments independently increase the risk of gastric cancer

Covariates Univariate analysis Multivariate analysis
p OR 95 % CI p
First modela
  Age < 0.001 1.04 1.02 - 1.05 < 0.001
  Gender < 0.001 3.58 2.10 - 6.09 < 0.001
  rs744166 0.007 1.64 1.16 - 2.31 0.005
  EPIYA-C number < 0.001 2.28 1.41 - 3.68 0.001
Second modelb
  Age < 0.001 1.05 1.05 - 1.06 < 0.001
  Gender < 0.001 3.23 2.02 - 5.17 < 0.001
  rs744166 plus EPIYA-C number < 0.001 3.01 2.29 - 3.97 < 0.001
  1. The Hosmer-Lemeshow tests showed good fit for models a(10 steps, 8 degrees of freedom; p = 0.42) b(10 steps, 8 degrees of freedom; p = 0.25), OR, odds ratio; 95 % CI: confidence interval. We constructed two models studying the loci, according to the amount of G rs744166 allele, treated as categorical variables having 3 values with 0 meaning the AA genotype, 1 the carrier of one G allele and 2 the GG genotype. In the second model the variable was obtained by the sum of the amount of STAT3 G allele and the number of EPIYA-C segments