Skip to main content

Table 2 Univariate and multivariate logistic regression analysis with clinical parameters and profiles of TMEM expression in tumors. (A) metastatic and non-metastatic samples. (B) Low and high Fuhrman grade samples. Confidence intervals and p-values in multivariate logistic regression were calculated using 10000-times bootstrap and were reported for penalized model. ROC AUC and R2 parameters from both bootstrap and cross-validation were reported. Abbreviations: OR – odds ratio. 95 % CI OR – 95 % confidence interval. AIC – Akaike Information Criterion. n – number of samples. ROC AUC – receiver operating characteristics area under curve parameter. VIF – variance inflation factor

From: Expression of pre-selected TMEMs with predicted ER localization as potential classifiers of ccRCC tumors

(A) Metastases Univariate Multivariate
p-value q-value OR 95%CI OR AIC n p-value q-value OR 95%CI OR AIC n VIF ROC AUC R2 ROC AUC R2
Lower Upper Lower Upper Bootstrap Cross-validation
Average tumor size [mm] 0.0001 0.004 1.070 1.038 1.113 53.46 76 0.0002 0.006 1.087 1.051 1.162 38.09 70 1.195 0.919 0.565 0.932 0.800
TMEM72 expression 0.009 0.089 0.776 0.634 0.931 60.67 70 0.0113 0.105 0.738 0.555 0.884 1.195
Symptoms 0.002 0.032 7.500 2.199 28.511 66.19 76 Variables not in the multivariate model
TMEM116 expression 0.009 0.094 0.601 0.394 0.863 68.84 76
TMEM61 expression 0.019 0.139 0.790 0.634 0.945 60.44 68
EPAS1 expression 0.102 0.366 0.684 0.428 1.079 73.93 76
(B) Fuhrman grade Univariate Multivariate
p-value q-value OR 95%CI OR AIC n p-value q-value OR 95%CI OR AIC n VIF ROC AUC R2 ROC AUC R2
Lower Upper Lower Upper Bootstrap Cross-validation
EPAS1 expression 0.00004 0.002 0.235 0.107 0.433 78.70 76 0.0003 0.008 0.265 0.117 0.476 62.80 75 1.143 0.898 0.600 0.919 0.798
Smoking 0.00177 0.018 4.764 1.837 13.153 98.75 76 0.0772 0.317 3.092 0.954 12.616 1.069
Average tumor size [mm] 0.00299 0.032 1.039 1.015 1.067 98.11 76 0.004 0.054 1.048 1.023 1.099 1.241
TMEM30B expression 0.00574 0.044 0.645 0.460 0.858 97.98 75 0.02 0.146 0.634 0.351 0.825 1.286
VHL expression 0.0208 0.066 0.529 0.295 0.882 103.21 76 Variables not in the multivariate model
TMEM72 expression 0.0255 0.150 0.832 0.699 0.970 95.22 70
TMEM45B expression 0.028 0.167 0.794 0.637 0.966 103.92 76
TMEM116 expression 0.0408 0.180 0.725 0.520 0.970 104.58 76
SLC35G2 expression 0.0442 0.222 0.811 0.651 0.985 103.38 75