Expression of pre-selected TMEMs with predicted ER localization as potential classifiers of ccRCC tumors

Wrzesiński, Tomasz; Szelag, Malgorzata; Cieślikowski, Wojciech A.; Ida, Agnieszka; Giles, Rachel; Zodro, Elżbieta; Szumska, Joanna; Poźniak, Joanna; Kwias, Zbigniew; Bluyssen, Hans A.R.; Wesoly, Joanna

doi:10.1186/s12885-015-1530-4

BMC Cancer

Table 2 Univariate and multivariate logistic regression analysis with clinical parameters and profiles of TMEM expression in tumors. (A) metastatic and non-metastatic samples. (B) Low and high Fuhrman grade samples. Confidence intervals and p-values in multivariate logistic regression were calculated using 10000-times bootstrap and were reported for penalized model. ROC AUC and R² parameters from both bootstrap and cross-validation were reported. Abbreviations: OR – odds ratio. 95 % CI OR – 95 % confidence interval. AIC – Akaike Information Criterion. n – number of samples. ROC AUC – receiver operating characteristics area under curve parameter. VIF – variance inflation factor

From: Expression of pre-selected TMEMs with predicted ER localization as potential classifiers of ccRCC tumors

(A) Metastases	Univariate							Multivariate
	p-value	q-value	OR	95%CI OR		AIC	n	p-value	q-value	OR	95%CI OR		AIC	n	VIF	ROC AUC	R²	ROC AUC	R²
	p-value	q-value	OR	Lower	Upper	AIC	n	p-value	q-value	OR	Lower	Upper	AIC	n	VIF	Bootstrap		Cross-validation
Average tumor size [mm]	0.0001	0.004	1.070	1.038	1.113	53.46	76	0.0002	0.006	1.087	1.051	1.162	38.09	70	1.195	0.919	0.565	0.932	0.800
TMEM72 expression	0.009	0.089	0.776	0.634	0.931	60.67	70	0.0113	0.105	0.738	0.555	0.884	38.09	70	1.195	0.919	0.565	0.932	0.800
Symptoms	0.002	0.032	7.500	2.199	28.511	66.19	76	Variables not in the multivariate model
TMEM116 expression	0.009	0.094	0.601	0.394	0.863	68.84	76
TMEM61 expression	0.019	0.139	0.790	0.634	0.945	60.44	68
EPAS1 expression	0.102	0.366	0.684	0.428	1.079	73.93	76
(B) Fuhrman grade	Univariate							Multivariate
	p-value	q-value	OR	95%CI OR		AIC	n	p-value	q-value	OR	95%CI OR		AIC	n	VIF	ROC AUC	R²	ROC AUC	R²
	p-value	q-value	OR	Lower	Upper	AIC	n	p-value	q-value	OR	Lower	Upper	AIC	n	VIF	Bootstrap		Cross-validation
EPAS1 expression	0.00004	0.002	0.235	0.107	0.433	78.70	76	0.0003	0.008	0.265	0.117	0.476	62.80	75	1.143	0.898	0.600	0.919	0.798
Smoking	0.00177	0.018	4.764	1.837	13.153	98.75	76	0.0772	0.317	3.092	0.954	12.616			1.069
Average tumor size [mm]	0.00299	0.032	1.039	1.015	1.067	98.11	76	0.004	0.054	1.048	1.023	1.099			1.241
TMEM30B expression	0.00574	0.044	0.645	0.460	0.858	97.98	75	0.02	0.146	0.634	0.351	0.825			1.286
VHL expression	0.0208	0.066	0.529	0.295	0.882	103.21	76	Variables not in the multivariate model
TMEM72 expression	0.0255	0.150	0.832	0.699	0.970	95.22	70
TMEM45B expression	0.028	0.167	0.794	0.637	0.966	103.92	76
TMEM116 expression	0.0408	0.180	0.725	0.520	0.970	104.58	76
SLC35G2 expression	0.0442	0.222	0.811	0.651	0.985	103.38	75

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ISSN: 1471-2407

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