Table 1 Characteristics of studies included in the final meta-analysis of Ki-67 expression and prognosis of NSCLC
First-Author and Year | Country | Total Patients, H/L | Mean age | Gender (M/F) | History | TNM Stage | Antibody and dilution | Cut-off (%) | Followup (median Month) | Survival Analysis, year | HR estimated | OS/DFS HR (95%CI) | Study Quality |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ahn 2014 | Korea | 109,20/89 | 65 | 65/44 | NSCLC | I-III | Anti-Ki67; 1:50 | 40 | 30 | OS/DFS,5 | S.urves | O:1.60(0.74-3.44) D:2.875(1.326-6.234) | 34 |
Cagini 2000x | Italy | 99,43/56 | 66 | 91/8 | NSCLC | I-II | MIB-1; 1:100 | 20 | 41 | OS, 5 | Events | O:1.33(0.72-2.43) | 31 |
D’amico 1999 | USA | 408,204/204 | 62.9 | 269/139 | NSCLC | I | MIB-1, NA | 7 | 60 | OS,5 | Events | O:1.41(0.99-2.00) | 33 |
Demarchi 2000 | Brazil | 64,32/32 | 59.8 | 43/21 | ADC | I-III | MIB-1; 1:400 | 22.2 | 51.9 | OS,5 | R | O:0.49(0.20-1.22) | 31 |
Fontanini 1996 | Italy | 65,31/34 | 46 | 63/7 | NSCLC | I-III | MIB-1; 1:200 | 30.2 | 45 | OS,3 | R | O:1.05(0.83-1.324) | 34 |
Haga 2003 | Japan | 187,112/75 | NA | 120/67 | ADC,SCC | I | MIB-1; 1:100 | 10 | 120 | OS,5 | Events | O:3.636(1.267-10.439) | 33 |
Harpole 1996 | USA | 275,109/106 | 63 | 177/98 | NSCLC | I | Anti-Ki67; NA | 7 | 68 | OS, 5 | Events | O:1.53(1.00-2.37) | 34 |
Hayashi 2001 | Japan | 98,36/62 | 62.7 | 56/42 | ADC | I-III | MIB-1; 1:200 | 12.6 | 60 | OS,5 | R | O:2.0(1.1-3.8) | 29 |
Hommura 2000 | Japan | 215,116/99 | 63.3 | 144/71 | NSCLC | I-IV | MIB-1; 1:50 | 30 | 84 | OS,3 | R | O:2.53(1.35-4.72) | 34 |
Huang 2005 | Japan | 173,117/56 | 67 | 116/57 | NSCLC | I-III | MIB-1; 1:40 | 25 | 77 | OS,5 | Events | O:1.56(0.99-2.44) | 32 |
Ishida 1997 | Japan | 114,57/57 | 64.9 | 59/55 | ADC | I-II | MIB-1; 1:50 | 22.7 | 28.5 | OS,5 | S.urves | O:8.50(3.52-20.53) | 32 |
Kaira 2008 | Japan | 361,186/135 | 67 | 196/125 | NSCLC | I-III | MIB-1; 1:40 | 25 | 48 | OS,5 | R | O:0.667(0.271-1.643) | 32 |
Liu 2012a | China | 494,113/381 | 61 | 366/128 | ADC,SCC | I-IV | Anti-Ki67; 1:200 | 50 | 25.9 | OS,5 | R | O:1.583(1.100-2.277) | 32 |
Liu 2012b | China | 174,88/79 | 60 | 133/41 | ADC,SCC | I-IV | Anti-Ki67; 1:200 | 50 | 25 | OS,5 | R | O:1.681(0.487-5.797) | 32 |
Maddau 2006 | Italy | 180,103/77 | 65.5, | 151/29 | NSCLC | I-III | MIB-1; 1:50 | 25 | 3-47 | OS,3 | R | O:0.79(0.55-1.15) | 29 |
Mehdi 1998 | USA | 243,154/49 | 63.5 | 184/76 | NSCLC | I-II | MIB-1; 1:150 | 25 | 60 | OS/DFS,3 | S.urves | O:1.60(1.06-2.41) D:1.58(1.06-2.41) | 36 |
Minami 2002 | Japan | 47,22/25 | 64 | 28/19 | ADC | I | MIB-1; NA | 20 | 89 | OS,5 | R | O:1.022(0.96-1.08) | 33 |
Navaratnam 2012a | Canada | 79,37/42 | 69.2 | 47/32 | NSCLC | I-II | MIB-1; 1:50 | 20 | 36 | OS,3 | R | O: 1.81(0.93-3.53) | 30 |
Navaratnam 2012b | Cadana | 58,20/38 | 62.8 | 23/35 | NSCLC | I-II | MIB-1; 1:50 | 10 | 36 | OS,3 | R | O:1.31(0.68-2.52) | 24 |
Nguyen 2000 | Czech | 89,34/55 | 60 | 73/16 | NSCLC | I-IV | MIB-1; NA | 30 | 36 | OS,3 | S.urves | O:2.15(1.21-3.78) | 28 |
Pence 1993 | USA | 61,15/46 | 63 | 56/5 | NSCLC | I-IV | Anti-Ki67; 1:100 | PI 3.5 | 38 | OS,5 | S. urves | O:2.18(1.00-4.78) | 29 |
Poleri 2003 | Argentina | 50,28/22 | 60.8 | NA | ADC,SCC | I | MIB-1; NA | 33 | 59 | DFS,5 | Events | D:4.10(1.98-8.46) | 33 |
Puglisi 2002 | Italy | 81,28/53 | 62.5 | NA | ADC,SCC | I-III | MIB-1; 1:100 | 34.2 | 115.76 | OS,5 | R | O: 1.29(0.71-2.31) | 33 |
Ramnath 2001 | USA | 212,118/94 | 63.7 | 111/101 | NSCLC | I-IV | MIB-1; 1:100 | 25 | 24.3 | OS,3 | S. Curve | O:1.41(0.93-2.12) | 31 |
Shiba 2000 | Japan | 156,81/75 | 62.4 | 112/44 | NSCLC | I-III | MIB-1; 1:100 | 20 | 49 | OS,5 | S. Curve | O:2.20(1.38-3.53) | 34 |
Takahashi 2002 | Japan | 62,22/40 | 66.9 | 40/22 | ADC,SCC | I-II | MIB-1; 1:100 | 25 | 3.9 | DFS,5 | R | D:1.02(0.32-3.30) | 33 |
Warth 2014 | Germany | 482,230/252 | 63.2 | NA | ADC | I-IV | MIB-1, 1:500 | 25 | 45.6 | OS/DFS,5 | S. Curve | O:1.86(1.29-2.69) D:1.29(1.02-1.64) | 29 |
Woo 2009 | Japan | 184,79/105 | 67.8 | 92/92 | NSCLC | I | MIB-1; NA | 10 | 35.9 | DFS,5 | R | D:3.84(1.18-12.45) | 34 |
Wu 2013 | China | 192,120/72 | 59 | 104/88 | NSCLC | I-III | Anti-Ki67; 1:200 | 10 | 60 | OS/DFS,5 | R | O:2.829(1.26-4.525) D:2.929(2.184-4.928) | 32 |
Yamashita 2011 | Japan | 44,13/31 | NA | 25/19 | NSCLC | I | Anti-Ki67; 1:100 | 5 | 60 | DFS,5 | R | D:12.5(1.1-140.7) | 33 |
Yoo 2007 | Korea | 219,17/209 | 65.8 | 168/51 | ADC,SCC | I-III | Anti-Ki67; NA | 30 | 38.9 | OS,5 | R | O:0.827(0.319-2.140) | 36 |
Zhong 2014 | China | 270,66/204 | 62 | 192/78 | ADC,SCC | I-III | Anti-Ki67; 1:200 | 50 | 60 | OS,5 | R | O:2.179(1.096-4.333) | 34 |