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Table 3 miRNAs and expression of their predicted targets as assessed by immunohistochemistry (IPX) for the initial cohort of 35 BRCA1 and 52 sporadic basal cancers

From: Comparative microRNA profiling of sporadic and BRCA1 associated basal-like breast cancers

miRNA miRNA expression up or down in BRCA1 vs. sporadic cancers Fold change miRNA adjusted p value (BRCA1 vs. sporadic) Predicted target gene IPX expression up or down in BRCA1 vs. sporadic cancers Positive IPX in BRCA1, n (%) Positive IPX in sporadic, n (%) p value (chi square) positive or negative on IPX p value (Mann–Whitney) on IPX score out of 7
hsa-miR-509-5p Up 2.53 0.004 FOXP1 Down 6 (30 %) 37 (76 %) <0.001 <0.001
hsa-miR-1285 Up 2.68 0.042
hsa-miR-1826 Up 3.02 <0.001
hsa-miR-220b Up 3.76 <0.001
hsa-miR-1826 Up 3.02 <0.001 Cyclin D1 Down 8 (36 %) 30 (65 %) 0.025 0.004
hsa-miR-576-3p Up 3.26 0.001
hsa-miR-638 Up 3.04 0.036
hsa-miR-30c-1* Up 4.51 <0.001 NRP1 Down 2 (10 %) 23 (50 %) 0.002 0.003
hsa-miR-1285 Up 2.69 0.043
hsa-miR-129-3p Up 6.03 <0.001
hsa-miR-29a* Down 3.12 <0.001 CD99 Up 17 (85 %) 7 (37 %) 0.002 0.005
hsa-miR-130b* Down 2.95 <0.006
hsa-miR-132* Down 2.48 0.024
hsa-miR-340* Down 3.09 0.028