Fig. 8

Schematic diagrams illustrating the potential mechanism of how Lck functions in mitochondria. As shown in Jcam, CRIF1 is a crucial component of the mitochondrial translational machinery and stabilizes the electron transport chain (ETC) complex. In Jurkat, Lck interaction with CRIF1 in mitochondria may disrupt CRIF1’s association with Tid1 and other translational components in the mitoribosome. Reduced levels of mitochondrion-encoded OXPHOS polypeptide and a defect in subsequent insertion into the inner membrane may lead to a decrease in mitochondrial respiration. The level of mitochondrion-encoded OXPHOS mRNA, however, remains unchanged in the mitochondrial matrix between Jurkat and Jcam cells