Table 1 Pathway enrichment analysis using Reactome database of gene groups defined via correlation analysis of genome-wide gene expression data (for details see Fig. 3)

A: Positively correlating with PPARα-wt protein

Metabolism of lipids and lipoproteins

0.00002

10.4

Biological oxidations

0.005

2.89

Integration of energy metabolism

0.011

2.70

Metabolism of amino acids

0.015

2.48

Metabolism of carbohydrates

0.017

1.51

B: Positively correlating with PPARα-wt/PPARα-tr protein ratio

Signaling by GPCR

0.07

0.24

Hormone biosynthesis

0.09

0.17

Synaptic Transmission

0.19

0.15

Apoptosis

0.37

0.14

Integration of energy metabolism

0.40

0.09

Intersection between the groups A and B

Integration of energy metabolism

0.0008

7.79

Hemostasis

0.002

6.36

Signaling by BMP

0.08

0.81

HIV Infection

0.028

0.74

DNA Repair

0.14

0.55

C: Negatively correlating with PPARα-tr protein

Signaling in Immune system

0.029

1.06

Cell Cycle, Mitotic

0.047

0.88

Signaling by Wnt

0.042

0.63

Apoptosis

0.13

0.60

IL3 signaling

0.12

0.40

Intersection between the groups A and C

Full name

RBMS1

RNA Binding Motif, Single Stranded Interacting Protein 1

POFUT1

Protein O-Fucosyltransferase 1

DEAF1

DEAF1 Transcription Factor (also: suppressin)

SLC6A9

Solute Carrier Family 6 (Neurotransmitter Transporter, Glycine), Member 9

FLCN

Folliculin