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Table 1 Pathway enrichment analysis using Reactome database of gene groups defined via correlation analysis of genome-wide gene expression data (for details see Fig. 3)

From: The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes

Selected gene groups Pathway term P-value Enrichment score
A: Positively correlating with PPARα-wt protein Metabolism of lipids and lipoproteins 0.00002 10.4
  Biological oxidations 0.005 2.89
  Integration of energy metabolism 0.011 2.70
  Metabolism of amino acids 0.015 2.48
  Metabolism of carbohydrates 0.017 1.51
B: Positively correlating with PPARα-wt/PPARα-tr protein ratio Signaling by GPCR 0.07 0.24
  Hormone biosynthesis 0.09 0.17
  Synaptic Transmission 0.19 0.15
  Apoptosis 0.37 0.14
  Integration of energy metabolism 0.40 0.09
Intersection between the groups A and B Integration of energy metabolism 0.0008 7.79
  Hemostasis 0.002 6.36
  Signaling by BMP 0.08 0.81
  HIV Infection 0.028 0.74
  DNA Repair 0.14 0.55
C: Negatively correlating with PPARα-tr protein Signaling in Immune system 0.029 1.06
  Cell Cycle, Mitotic 0.047 0.88
  Signaling by Wnt 0.042 0.63
  Apoptosis 0.13 0.60
  IL3 signaling 0.12 0.40
Intersection between the groups A and C Full name Functions
RBMS1 RNA Binding Motif, Single Stranded Interacting Protein 1 Single-stranded DNA binding protein interacting with upstream region of C-MYC gene.
POFUT1 Protein O-Fucosyltransferase 1 Metabolic relevant enzyme, catalyzer of the fucose attachement to serine/threonine residues.
DEAF1 DEAF1 Transcription Factor (also: suppressin) Secreted factor, acts as an inhibitor of cell proliferation by arresting cells in the G0 or G1 phase.
SLC6A9 Solute Carrier Family 6 (Neurotransmitter Transporter, Glycine), Member 9 Terminates the action of glycine by its high affinity sodium-dependent reuptake
FLCN Folliculin Not clearly classified protein, involved in energy and/or nutrient sensing via AMPK and mTOR signaling pathways.