Table 5 Multivariate Cox Regression for Survival

Variable set

Hazard ratio

95 % CI

p-value

Extrahepatic metastases (yes)

2.13

0.97 - 4.64

0.058

Liver volume (≥ 1376 mL)

2.25

1.01 - 5.02

0.047

Maximum diameter of liver metastases (≥ 3.9 cm)

3.12

1.39 - 7.02

0.006

Number of liver metastases (≥ 6)

1.48

0.69 - 3.14

0.312

Lines of chemotherapy (≥ 3)

2.48

1.15 - 5.36

0.021

Bone metastases only (yes)

1.56

0.70 - 3.47

0.279

Liver volume (≥ 1376 mL)

2.01

0.93 - 4.36

0.076

Maximum diameter of liver metastases (≥ 3.9 cm)

3.1

1.37 - 7.02

0.007

Number of liver metastases (≥ 6)

1.51

0.72 - 3.20

0.278

Lines of chemotherapy (≥ 3)

2.6

1.14 - 5.92

0.023

Variable set

Hazard ratio

95 % CI

p-value

Extrahepatic metastases (yes)

1.05

0.43 - 2.58

0.92

Liver volume (≥ 1376 mL)

2.17

0.90 - 5.22

0.084

Maximum diameter of liver metastases (≥ 3.9 cm)

3.1

1.31 - 7.36

0.01

Number of liver metastases (≥ 6)

1.13

0.49 - 2.59

0.782

Lines of chemotherapy (≥ 3)

1.81

0.83 - 3.97

0.138

Under local control in FU (yes)

0.29

0.11 - 0.73

0.009

Best response overall (OR, RECIST)

0.21

0.08 - 0.57

0.002

Bone metastases only (yes)

1.06

0.46 - 2.44

0.89

Liver volume (≥ 1376 mL)

2.16

0.92 - 5.03

0.075

Maximum diameter of liver metastases (≥ 3.9 cm)

3.05

1.22 - 7.61

0.017

Number of liver metastases (≥ 6)

1.12

0.48 - 2.59

0.796

Lines of chemotherapy (≥ 3)

1.8

0.80 - 4.01

0.154

Under local control in FU (yes)

0.29

0.12 - 0.70

0.006

Best response overall (OR, RECIST)

0.21

0.08 - 0.52

0.001