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Table 3 Distribution frequency of normal/CIN1, CIN2, and CIN3 + lesions by method of biopsy, grouped by 12 o’clock cervical location

From: Distribution of cervical intraepithelial neoplasia on the cervix in Chinese women: pooled analysis of 19 population based screening studies

O’clock location Diagnosis  
  Normal/CIN1 CIN2 CIN3+ Total ORCIN2+ 95 % CI ORCIN3+ 95 % CI
  n n/Nr(%) n n/Nr(%) n n/Nr(%) Nr Nr/N(%)       
Directed biopsy
1 728 91.8 35 4.4 30 3.8 793 13.1 0.775 0.547 1.098 0.624 0.387 1.006
2 391 86.3 26 5.7 36 7.9 453 7.5 1.376 0.961 1.971 1.394 0.880 2.209
3 168 91.3 6 3.3 10 5.4 184 3.0 0.827 0.470 1.456 0.901 0.444 1.831
4 486 83.6 49 8.4 95 7.9 581 9.6 2.572 1.900 3.481 2.959 2.026 4.323
5 436 88.4 26 5.2 31 6.3 493 8.1 1.135 0.788 1.635 1.076 0.668 1.735
6 319 90.9 15 4.2 17 4.8 351 5.8 0.871 0.564 1.345 0.807 0.045 1.437
7 442 83.7 37 7.0 49 9.3 528 8.7 1.689 1.211 2.355 1.678 1.095 2.572
8 553 88.5 41 6.6 31 5.0 625 10.3 1.130 0.802 1.592 0.849 0.528 1.365
9 138 87.9 7 4.5 12 7.6 157 2.6 1.195 0.699 2.042 1.317 0.677 2.562
10 651 89.7 32 4.4 43 5.9 726 12.0 1 / / 1 / /
11 672 92.1 31 4.2 27 3.7 730 12.0 0.749 0.523 1.073 0.608 0.372 0.996
12 405 91.6 16 3.6 21 4.8 442 7.3 0.793 0.525 1.198 0.785 0.459 1.342
Total 5389 88.9 321 5.3 353 5.8 6063 100.0       
Random biopsy
1 276 96.8 6 2.1 3 1.1 285 0.8 1.829 0.923 3.623 1.508 0.470 4.841
2 8321 98.3 80 0.9 67 0.8 8468 24.0 0.991 0.786 1.248 1.117 0.786 1.588
3 46 95.8 0 0.0 2 4.2 48 0.1 2.438 0.586 10.139 6.033 1.431 25.431
4 8646 98.1 94 1.1 74 0.8 8814 25.0 1.090 0.871 1.363 1.188 0.843 1.674
5 117 92.1 6 4.7 4 3.2 127 0.4 4.793 2.462 9.330 4.744 1.695 13.277
6 73 93.6 4 5.1 1 1.3 78 0.2 3.841 1.530 9.644 1.901 0.260 13.904
7 134 93.1 5 3.5 5 3.5 144 0.4 4.185 2.156 8.121 5.178 2.046 13.106
8 8488 97.9 108 1.2 70 0.8 8666 24.5 1.176 0.943 1.467 1.144 0.808 1.620
9 46 93.9 3 6.1 0 0.0 49 0.1 3.657 1.125 11.893 0 0 0
10 8187 98.2 87 1.0 59 0.7 8333 23.6 1 / / 1 / /
11 208 96.7 4 1.9 3 1.4 215 0.6 1.887 0.873 4.079 2.001 0.622 6.436
12 91 93.8 3 3.1 3 3.1 97 0.3 3.697 1.593 8.583 4.575 1.408 14.861
Total 34633 98.0 400 1.1 291 0.8 35324 100.0       
  1. CIN cervical intraepithelial neoplasia; OR odds ratios; CI confidence intervals