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Table 3 Correlation of cell survival with Clinical and Pathological Factors

From: Prospective cohort study using the breast cancer spheroid model as a predictor for response to neoadjuvant therapy – the SpheroNEO study

 

Cutoff

 
 

Mean

<35 %

≥35 %

 

Characteristics

%

P

n

%

n

%

P

All Patients

  

32

41.0

46

59.0

 

Age at diagnosis, years

 

.877

    

1.000

  ≤50

51.44

 

18

41.9

25

58.1

 

  >50

52.61

 

14

40.0

21

60.0

 

Mean

-

51

51

.817

Range

-

21-76

25-78

 

Tumor stage

 

.181

    

.603

  cT1/T2

49.40

 

24

42.9

32

57.1

 

  cT3/4

60.66

 

7

33.3

14

66.7

 

Nodal status

 

.813

    

1.000

  cN+

50.41

 

17

40.5

25

59.5

 

  cN-

52.20

 

15

42.9

20

57.1

 

Grading

 

.339

    

.486

  G1/2

55.34

 

15

36.6

26

63.4

 

  G3

48.09

 

16

45.7

19

54.3

 

  Not documented

  

-

 

-

  

Histologic type

 

.569

    

.439

  Ductal invasive/other

51.25

 

30

42.9

40

57.1

 

  Lobular invasive

58.29

 

2

25.0

6

75.0

 

HR status

 

.038

    

.042

  ER+/PR+

62.49

 

10

25.6

29

74.4

 

  ER+/PR-/Unknown

36.10

 

7

70.0

3

30.0

 

  ER-/unknown/PR+

47.82

 

1

50.0

1

50.0

 

  ER-/PR-

43.03

 

12

50.0

12

50.0

 

HER2 status

 

.000

    

<.0001

  Negative

58.34

 

17

28.8

42

71.2

 

  Positive

30.70

 

13

81.3

3

18.8

 
  1. PR, progesterone receptor; ER, estrogen receptor; HER2, human epidermal growth factor receptor; pCR, pathologic complete response