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Table 2 Combinatory effects of AdF35/MK or AdF35/Sur and Ad5/p53 on cell growth

From: Cytotoxic effects of replication-competent adenoviruses on human esophageal carcinoma are enhanced by forced p53 expression

Treatment Time (day) Cell numbers (×104)
(-) 2 174.3 ± 4.4
Ad5/LacZ 2 185.9 ± 2.4
Ad5/p53 2 98.3 ± 4.1b
AdF35/MK 2 133.7 ± 6.1a
AdF35/MK + Ad5/LacZ 2 141.9 ± 7.1
AdF35/MK + Ad5/p53 2 28.0 ± 2.1d
AdF35/Sur 2 147.7 ± 1.2a
AdF35/Sur + Ad5/LacZ 2 146.3 ± 1.8
AdF35/Sur + Ad5/p53 2 24.3 ± 3.0d
(-) 4 747.3 ± 5.1
Ad5/LacZ 4 718.2 ± 10.0
Ad5/p53 4 57.7 ± 5.6b
AdF35/MK 4 67.7 ± 7.0b
AdF35/MK + Ad5/LacZ 4 72.2 ± 1.5
AdF35/MK + Ad5/p53 4 3.3 ± 0.3d
AdF35/Sur 4 160.0 ± 3.0b
AdF35/Sur + Ad5/LacZ 4 134.9 ± 1.2
AdF35/Sur + Ad5/p53 4 19.3 ± 2.3d
(-) 6 1717.7 ± 1.3
Ad5/LacZ 6 1838.6 ± 7.2
Ad5/p53 6 1.2 ± 0.4b
AdF35/MK 6 12.0 ± 0.6b
AdF35/MK + Ad5/LacZ 6 20.3 ± 0.3
AdF35/MK + Ad5/p53 6 0 ± 0c
AdF35/Sur 6 40.3 ± 1.3b
AdF35/Sur + Ad5/LacZ 6 87.0 ± 3.8
AdF35/Sur + Ad5/p53 6 0 ± 0c
  1. YES-2 cells were uninfected or infected with Ad as indicated (AdF35/MK and AdF35/Sur: 1.2× 103 vp/cell; Ad5/p53 and Ad5/LacZ: 6.5× 103 vp/cell). Live cell numbers were determined with a trypan blue dye exclusion test. Mean percentages with SEs are shown (n = 3)
  2. aP < 0. 05, bP < 0. 01; comparing between Ad/p53-, AdF35/MK- or AdF35/Sur-infected cells, and uninfected or Ad5/LacZ-infected cells. cP < 0. 05, dP < 0. 01; comparing between AdF35/MK + Ad5/p53- or AdF35/Sur + Ad5/p53-infected cells, and AdF35/MK-, AdF35/Sur-, Ad5/p53-, AdF35/MK + Ad5/LacZ-infected or AdF35/Sur + Ad5/LacZ-infected cells