BMC Cancer

Table 2 Combinatory effects of AdF35/MK or AdF35/Sur and Ad5/p53 on cell growth

From: Cytotoxic effects of replication-competent adenoviruses on human esophageal carcinoma are enhanced by forced p53 expression

Treatment	Time (day)	Cell numbers (×10⁴)
(-)	2	174.3 ± 4.4
Ad5/LacZ	2	185.9 ± 2.4
Ad5/p53	2	98.3 ± 4.1^b
AdF35/MK	2	133.7 ± 6.1^a
AdF35/MK + Ad5/LacZ	2	141.9 ± 7.1
AdF35/MK + Ad5/p53	2	28.0 ± 2.1^d
AdF35/Sur	2	147.7 ± 1.2^a
AdF35/Sur + Ad5/LacZ	2	146.3 ± 1.8
AdF35/Sur + Ad5/p53	2	24.3 ± 3.0^d
(-)	4	747.3 ± 5.1
Ad5/LacZ	4	718.2 ± 10.0
Ad5/p53	4	57.7 ± 5.6^b
AdF35/MK	4	67.7 ± 7.0^b
AdF35/MK + Ad5/LacZ	4	72.2 ± 1.5
AdF35/MK + Ad5/p53	4	3.3 ± 0.3^d
AdF35/Sur	4	160.0 ± 3.0^b
AdF35/Sur + Ad5/LacZ	4	134.9 ± 1.2
AdF35/Sur + Ad5/p53	4	19.3 ± 2.3^d
(-)	6	1717.7 ± 1.3
Ad5/LacZ	6	1838.6 ± 7.2
Ad5/p53	6	1.2 ± 0.4^b
AdF35/MK	6	12.0 ± 0.6^b
AdF35/MK + Ad5/LacZ	6	20.3 ± 0.3
AdF35/MK + Ad5/p53	6	0 ± 0^c
AdF35/Sur	6	40.3 ± 1.3^b
AdF35/Sur + Ad5/LacZ	6	87.0 ± 3.8
AdF35/Sur + Ad5/p53	6	0 ± 0^c

YES-2 cells were uninfected or infected with Ad as indicated (AdF35/MK and AdF35/Sur: 1.2× 10³ vp/cell; Ad5/p53 and Ad5/LacZ: 6.5× 10³ vp/cell). Live cell numbers were determined with a trypan blue dye exclusion test. Mean percentages with SEs are shown (n = 3)
^aP < 0. 05, ^bP < 0. 01; comparing between Ad/p53-, AdF35/MK- or AdF35/Sur-infected cells, and uninfected or Ad5/LacZ-infected cells. ^cP < 0. 05, ^dP < 0. 01; comparing between AdF35/MK + Ad5/p53- or AdF35/Sur + Ad5/p53-infected cells, and AdF35/MK-, AdF35/Sur-, Ad5/p53-, AdF35/MK + Ad5/LacZ-infected or AdF35/Sur + Ad5/LacZ-infected cells

Back to article page

ISSN: 1471-2407

Contact us

Submission enquiries: bmccancer@biomedcentral.com
General enquiries: ORSupport@springernature.com