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Table 4 Cox proportional hazards regression analyses for progression free (PFS) and overall survival (OS) as a function of continuous and categorical (<5 CTCs vs. ≥5 CTCs) CTC-counts

From: Categorical versus continuous circulating tumor cell enumeration as early surrogate marker for therapy response and prognosis during docetaxel therapy in metastatic prostate cancer patients

  PFS OS
CTC-assessment Interval Patients (n=) Hazard ratio 95 % CI p= Hazard ratio 95 % CI p=
Continuous CTC-values q0 33 1.01 0.99-1.02 0.4 1.01 0.999-1.01 0.07
q1 33 1.02 1.0-1.05 0.04 1.02 1.01-1.04 0.01
q4 33 1.01 1.0-1.02 0.004 1.02 1.01-1.03 0.001
q10 23 1.02 0.99-1.04 0.3 1.03 1.01-1.05 0.004
Categorical CTC-counts q0 33 2.4 0.9-6.8 0.1 3.8 1.4-10.3 0.009
q1 33 4.3 1.6-11.8 0.005 4.5 1.9-10.8 0.001
q4 33 3.2 1.2-8.6 0.02 5.8 2.2-15.1 <0.001
q10 23 6.7 1.3-33.7 0.02 5.6 1.7-18.4 0.004
  1. p values indicate statistical significance