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Table 4 Multivariable adjusted geometric means (95 % CI) of volumetric mammographic density measures

From: Effects of statin use on volumetric mammographic density: results from the KARMA study

   

Geometric mean (95 % CI)a

 

N

Statin use

Percent dense volume (%)

Absolute dense volume (cm3)

Absolute non-dense volume (cm3)

BMI < 25 kg/m2

22,385

No

10.1 (10.0–10.1)

51.6 (51.3–52.0)

455 (452–457)

Yes

9.5 (9.3–9.7)

53.0 (51.5–54.5)

498 (485–511)

  

P value

<0.001

0.09

<0.001

BMI 25–30 kg/m2

13,273

No

6.5 (6.5–6.6)

62.5 (62.0–62.9)

887 (882–893)

Yes

6.4 (6.2–6.5)

62.5 (61.1–64.0)

914 (895–933)

  

P value

0.04

0.94

0.01

BMI > 30 kg/m2

5,444

No

4.8 (4.7–4.8)

68.9 (68.1–69.6)

1362 (1350–1416)

Yes

4.8 (4.7–4.9)

69.9 (67.9–72.0)

1385 (1352–1419)

  

P value

0.88

0.38

0.23

Premenopausal

17,855

No

9.7 (9.7–9.8)

62.9 (62.4–63.3)

573 (569–576)

  

Yes

9.3 (8.8–9.7)

62.1 (58.6–65.9)

598 (567–632)

  

P value

0.04

0.69

0.12

Postmenopausal

23,247

No

6.8 (6.8–6.8)

52.9 (52.6–53.2)

720 (716–724)

  

Yes

6.5 (6.4–6.6)

53.9 (53.1–54.8)

767 (755–779)

  

P value

<0.001

0.04

<0.001

Never HRTb

14,407

No

6.7 (6.7–6.8)

52.9 (52.5–53.2)

724 (719–729)

  

Yes

6.4 (6.3–6.5)

53.4 (52.3–54.5)

760 (747–774)

  

P value

<0.001

0.38

<0.001

Ever HRTb

6,475

No

6.9 (6.8–6.9)

53.0 (52.5–53.6)

723 (718–729)

  

Yes

6.6 (6.5–6.8)

55.2 (53.7–56.7)

771 (755–787)

  

P value

0.02

0.01

<0.001

P interactionb

  

0.61

0.03

0.11

  1. aAll mammographic density measures were log transformed prior to analysis and the values shown are on a back-transformed scale. bIn postmenopausal women only. P value refers to F-test for between-statin group differences in geometric means. P interaction refers to the P value of the multiplicative interaction term
  2. Model 4: Adjusted for age (years), body mass index (kg/m2), menopausal status (pre, peri/unknown, post), HRT use (never, former, current), parity/age at first birth (nulliparous, 1 child age at first birth < 25 years, 1 child age at first birth ≥ 25 years, 2 children age at first birth < 25 years, 2 children age at first birth ≥ 25 years, ≥ 3 children age at first birth < 25 years, ≥ 3 children age at first birth ≥ 25 years), age at menarche (years), education level (compulsory, gymnasium, university), smoking (never, former, current), alcohol consumption (nondrinker, 0,1–1,9 g/day, 2.0–4.9 g/day, 5.0–9.9 g/day, ≥10 g/day) and benign breast disease (yes vs. no), low-dose aspirin use (yes vs. no) and metformin use (yes vs. no)
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BMC Cancer

ISSN: 1471-2407

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