Table 1 Descriptive characteristics of the study population, overall and stratified by current statin use
From: Effects of statin use on volumetric mammographic density: results from the KARMA study
Participant characteristica | Total | Statin use | P value | |
|---|---|---|---|---|
| Â | Â | No | Yes | Â |
N = 37,765 | N = 3,337 | |||
Age (years), mean (SD) | 55.0 (9.8) | 54.2 (9.6) | 63.8 (6.9) | <0.001 |
Body mass index (kg/m2), mean (SD) | 25.4 (4.2) | 25.2 (4.2) | 27.1 (4.6) | <0.001 |
Age at menarche (years), mean (SD) | 13.1 (1.5) | 13.1 (1.5) | 13.3 (1.5) | <0.001 |
Parity, % (N) | Â | Â | Â | 0.54 |
0 | 12.1 (4,979) | 12.2 (4,582) | 11.9 (397) | |
1 | 14.1 (5,792) | 14.0 (5,294) | 15.0 (498) | |
2 | 48.5 (19,901) | 48.5 (18,296) | 48.2 (1,605) | |
> = 3 | 25.3 (10,363) | 25.3 (9,533) | 24.9 (830) | |
Age at first birth (years), mean (SD) | 27.1 (5.2) | 27.2 (5.2) | 25.0 (4.6) | <0.001 |
Menopausal status, % (N) | Â | Â | Â | <0.001 |
Premenopausal | 40.2 (16,506) | 43.1 (16,272) | 7.0 (234) | |
Perimenopausal/unknown | 3.3 (1,349) | 3.5 (1,304) | 1.4 (45) | |
Postmenopausal | 56.6 (23,247) | 53.5 (20,189) | 91.6 (3,058) | |
Oral contraceptive use, % (N) | 79.7 (32,602) | 80.5 (30,257) | 70.9 (2,345) | <0.001 |
Hormone replacement therapy, % (N) | Â | Â | Â | <0.001 |
Never | 80.5 (30,791) | 81.7 (28,809) | 65.6 (1,982) | |
Former | 15.5 (5,945) | 14.3 (5,040) | 30.0 (905) | |
Current | 4.0 (1,521) | 4.0 (1,395) | 4.2 (126) | |
Benign breast disease, % (N) | 22.1 (8,919) | 22.0 (8,156) | 23.3 (763) | 0.09 |
Family history of breast cancer, % (N) | 13.2 (5,236) | 13.2 (4,815) | 13.2 (421) | 0.91 |
Low-dose aspirin use, % (N) | 4.7 (1,911) | 2.2 (833) | 32.3 (1,078) | <0.001 |
Metformin use, % (N) | 1.6 (666) | 0.7 (263) | 12.1 (403) | <0.001 |
Education, % (N) | Â | Â | Â | <0.001 |
Compulsory | 14.4 (5,705) | 12.9 (4,726) | 31.2 (979) | |
Gymnasium | 31.6 (12,557) | 31.9 (11,664) | 28.5 (893) | |
University | 54.0 (21,440) | 55.2 (20,178) | 40.3 (1,262) | |
Smoking status, % (N) | Â | Â | Â | <0.001 |
Never | 48.2 (19,750) | 48.8 (18,400) | 40.6 (1,350) | |
Former | 39.7 (16,269) | 39.1 (14,726) | 46.4 (1,543) | |
Current | 12.2 (4,984) | 12.1 (4,551) | 13.0 (433) | |
Alcohol (g/week), % (N) | Â | Â | Â | <0.001 |
0 | 19.4 (7,912) | 18.9 (7,090) | 24.9 (822) | |
1–25 | 24.0 (9,788) | 24.3 (9,110) | 20.5 (678) | |
25–50 | 28.1 (11,471) | 28.4 (10,640) | 25.2 (831) | |
50–100 | 14.6 (5,949) | 14.6 (5,481) | 14.2 (468) | |
>100 | 13.9 (5,666) | 13.8 (5,162) | 15.3 (504) | |