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Table 1 Pharmacokinetic parameters of YL529 after oral administration with single dose of 150 mg/kg in mice

From: A small molecular agent YL529 inhibits VEGF-D-induced lymphangiogenesis and metastasis in preclinical tumor models in addition to its known antitumor activities

Pharmacokinetic parameter

Value

AUC(0-∞)(mg/L*h)

170.95

AUC(0-t)(mg/L*h)

167.32

t1/2β(h)

6.03

T1/2α(h)

1.39

t1/2z(h)

4.11

Cmax(mg/L)

18.03

Tmax(h)

2.00

  1. Data were expressed as the mean ± SD compared with vehicle. SPSS (SPSS, IL) software was used for statistical analysis (n = 3; *p < 0.05)