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Table 1 Relationship between c-Met/HGF expression and clinicopathological features

From: c-Met in esophageal squamous cell carcinoma: an independent prognostic factor and potential therapeutic target

Variable c-Met expression P-value HGF expression P-value
Low High Low High
Age (mean = 64 years old) <64 15 36 0.769 33 18 0.219
≥64 17 36 28 25
Gender Male 27 59 0.762 53 33 0.178
Female 5 13 8 10
Smoking historya Presence 27 56 0.802 49 34 0.987
Absence 5 12 10 7
Alcohol consumption historya Presence 25 54 0.77 49 30 0.116
Absence 6 11 7 10
Tumor sizeb (mean = 48.7 mm) <48.7 20 38 0.357 35 23 0.694
≥48.7 12 34 26 20
Tumor differentiationb Well 9 17 0.831 10 16 0.024c
Moderate 18 45 39 24
Poor 5 10 12 3
Growth patternb INFa 8 18 0.901 16 10 0.568
INFb 18 43 37 24
INFc 6 11 8 9
Lymphatic invasionb ly0 8 23 0.475 22 9 0.097
ly1–3 24 49 39 34
Vessel invasionb v0 11 15 0.141 16 10 0.73
v1–3 21 57 45 33
Tumor depthd T1/T2 17 20 0.013c 27 10 0.028c
T3/T4 15 52 34 33
Lymph node metastasisd N0 13 23 0.39 27 9 0.014c
N1 19 49 34 34
Distant metastasisde M0 29 66 0.862 58 37 0.107
M1 3 6 3 6
Pathological staged I/II 23 32 0.010c 38 17 0.022c
III/IV 9 40 23 26
HGF expression Low 21 40 0.336    
High 11 32   
  1. HGF hepatocyte growth factor, INF infiltration
  2. aData were not available for a few patients
  3. bHistopathological features based on the Japanese Classification of Esophageal Cancer, 10th edition (Japan Esophageal Society 2009)
  4. c indicates statistical significance
  5. dTumor-node-metastasis (TNM) classification based on the 6th edition of the TNM classification of malignant tumors [31]
  6. eAll cases of distant metastasis were that of the supraclavicular lymph nodes