c-Met in esophageal squamous cell carcinoma: an independent prognostic factor and potential therapeutic target

BMC Cancer

Table 1 Relationship between c-Met/HGF expression and clinicopathological features

Variable		c-Met expression		P-value	HGF expression		P-value
Variable		Low	High	P-value	Low	High	P-value
Age (mean = 64 years old)	<64	15	36	0.769	33	18	0.219
Age (mean = 64 years old)	≥64	17	36	0.769	28	25	0.219
Gender	Male	27	59	0.762	53	33	0.178
Gender	Female	5	13	0.762	8	10	0.178
Smoking history^a	Presence	27	56	0.802	49	34	0.987
Smoking history^a	Absence	5	12	0.802	10	7	0.987
Alcohol consumption history^a	Presence	25	54	0.77	49	30	0.116
Alcohol consumption history^a	Absence	6	11	0.77	7	10	0.116
Tumor size^b (mean = 48.7 mm)	<48.7	20	38	0.357	35	23	0.694
Tumor size^b (mean = 48.7 mm)	≥48.7	12	34	0.357	26	20	0.694
Tumor differentiation^b	Well	9	17	0.831	10	16	0.024^c
	Moderate	18	45		39	24
	Poor	5	10		12	3
Growth pattern^b	INFa	8	18	0.901	16	10	0.568
	INFb	18	43		37	24
	INFc	6	11		8	9
Lymphatic invasion^b	ly0	8	23	0.475	22	9	0.097
Lymphatic invasion^b	ly1–3	24	49	0.475	39	34	0.097
Vessel invasion^b	v0	11	15	0.141	16	10	0.73
Vessel invasion^b	v1–3	21	57	0.141	45	33	0.73
Tumor depth^d	T1/T2	17	20	0.013^c	27	10	0.028^c
Tumor depth^d	T3/T4	15	52	0.013^c	34	33	0.028^c
Lymph node metastasis^d	N0	13	23	0.39	27	9	0.014^c
Lymph node metastasis^d	N1	19	49	0.39	34	34	0.014^c
Distant metastasis^de	M0	29	66	0.862	58	37	0.107
Distant metastasis^de	M1	3	6	0.862	3	6	0.107
Pathological stage^d	I/II	23	32	0.010^c	38	17	0.022^c
Pathological stage^d	III/IV	9	40	0.010^c	23	26	0.022^c
HGF expression	Low	21	40	0.336
HGF expression	High	11	32	0.336

HGF hepatocyte growth factor, INF infiltration
^aData were not available for a few patients
^bHistopathological features based on the Japanese Classification of Esophageal Cancer, 10th edition (Japan Esophageal Society 2009)
^c indicates statistical significance
^dTumor-node-metastasis (TNM) classification based on the 6th edition of the TNM classification of malignant tumors [31]
^eAll cases of distant metastasis were that of the supraclavicular lymph nodes

ISSN: 1471-2407