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Table 3 Results of Cox regression analyses for clinicopathological factors and CXCL16 in stromal cells (model 1) and co-expression of CXCL16 in cancer and stromal cells (model 2*)

From: Prognostic impact of CXCL16 and CXCR6 in non-small cell lung cancer: combined high CXCL16 expression in tumor stroma and cancer cells yields improved survival

Factor

HR

CI 95 %

P

Tumor stage

  

<0.001†

T1

1.00

  

T2

1.60

(0.97–2.64)

0.065

T3

3.80

(2.13–6.77)

<0.001

Nodal stage

  

<0.001†

N0

1.00

  

N1

2.01

(1.30–3.11)

0.002

N2

3.08

(1.74–5.44)

<0.001

Differentiation

  

0.009†

Well

1.00

  

Poor

1.17

(1.12–3.85)

0.020

Moderate

2.08

(0.63–2.20)

0.618

Performance status

  

0.040†

0

1.00

  

1

1.52

(1.02–2.26)

0.040

2

2.15

(0.94–4.91)

0.069

Vascular infiltration

   

No

1.00

  

Yes

1.70

(1.01–2.87)

0.046

Histology

  

<0.001†

Squamous carcinoma

1.00

  

Adenocarcinoma

2.23

(1.48–3.35)

<0.001

Large cell carcinoma

0.80

(0.39–1.66)

0.555

CXC16 stromal cells

   

Low

1

  

High

0.55

(0.35–0.87)

0.011

CXCL16 cancer and stromal cells*

  

0.031†

Low/Low

1.00

  

Low/High + High/Low

0.57

(0.35–0.93)

0.023

Low/Low

0.42

(0.20–0.88)

0.022

  1. †Overall significance as prognostic marker. HR, hazard ratio; CI 95 %, 95 % confidence interval