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Table 3 Multivariate Cox regression analyses of clinicopathological variables, mRNA and protein expression levels, and breast cancer survival

From: Low expression levels of hepsin and TMPRSS3 are associated with poor breast cancer survival

Variable

B (SE)

Wald

RR (95 % CI)

P

Multivariate survival analysis with TMPRSS1 mRNA expression

 

Nodal status

 Negative

 

Ref.

  

 Positive

0.786 (0.339)

5.369

2.194 (1.129–4.265)

0.020

Tumor size

 T1

 

Ref.

  

 T2

0.678 (0.421)

2.597

1.970 (0.864–4.492)

0.107

 T3, T4

1.385 (0.504)

7.563

3.997 (1.489–10.729)

0.006

TMPRSS1 mRNA expression*

 Low

0.725 (0.318)

5.187

2.065 (1.106–3.856)

0.023

 High

 

Ref.

  

Multivariate survival analysis with TMPRSS3 mRNA expression

Nodal status

 Negative

 

Ref.

  

 Positive

1.091 (0.320)

11.596

2.976 (1.589–5.575)

0.001

Tumor size

 T1

 

Ref.

  

 T2

0.317 (0.373)

0.769

1.386 (0.668–2.874)

0.380

 T3, T4

1.256 (0.452)

7.720

3.511 (1.448–8.516)

0.005

TMPRSS3 mRNA expression*

   

 Low

0.745 (0.301)

6.111

2.106 (1.167–3.800)

0.013

 High

 

Ref.

  

Histology

 Ductal

0.472 (0.551)

0.734

1.603 (0.545–4.715)

0.391

 Lobular

1.501 (0.589)

6.497

4.487 (1.415–14.231)

0.011

 Medullary, others

 

Ref.

  

ER status

 Negative

0.628 (0.310)

4.109

1.873 (1.021–3.437)

0.043

 Positive

 

Ref.

  

Multivariate survival analysis with combined TMPRSS1-TMPRSS3 mRNA expression

Combined mRNA expression†

 Low

0.909 (0.325)

7.803

2.482 (1.312–4.698)

0.005

 Others

 

Ref.

  

Nodal status

 Negative

 

Ref.

  

 Positive

0.975 (0.360)

7.327

2.650 (1.309–5.368)

0.007

Tumor size

 T1

 

Ref.

  

 T2

0.481 (0.433)

1.233

1.617 (0.692–3.779)

0.267

 T3, T4

1.281 (0.505)

6.427

3.600 (1.337–9.691)

0.011

Multivariate survival analysis with combined hepsin-TMPRSS3 protein expression

Nodal status

 Negative

 

Ref.

  

 Positive

0.905 (0.227)

15.942

2.473 (1.586–3.857)

0.00007

Tumor size

 T1

 

Ref.

  

 T2

0.176 (0.235)

0.559

1.192 (0.752–1.888)

0.455

 T3, T4

0.891 (0.321)

7.696

2.438 (1.299–4.576)

0.006

Histology

 Ductal

0.255 (0.322)

0.628

1.291 (0.687–2.426)

0.428

 Lobular

0.903 (0.343)

6.909

2.466 (1.258–4.834)

0.009

 Medullary, others

 

Ref.

  

Tumor grade

 I

 

Ref.

  

 II

0.711 (0.290)

6.025

2.036 (1.154–3.591)

0.014

 III

0.532 (0.337)

2.493

1.702 (0.880–3.294)

0.114

Combined protein expression†

   

 Low

0.432 (0.214)

4.087

1.541 (1.013–2.342)

0.043

 Others

 

Ref.

  
  1. Note: Analyses included tumor grade, histology, tumor size, nodal status, ER and PR status
  2. B (SE), B coefficient with standard error; HR (95 % CI), hazard ratio of breast cancer death with a 95 % confidence interval; Ref., reference category in the multivariate analysis
  3. *The relative median value of mRNA expression level was used in the analyses
  4. †The ‘combined low group’ included all cases with low expression levels of both genes
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BMC Cancer

ISSN: 1471-2407

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