Fig. 1
From: A microRNA molecular modeling extension for prediction of colorectal cancer treatment
The conceptual visualization of miR-add-on algorithm. The step (1) simplifies two biological processes: (a) the transcription catalyzed by transcriptional activator or repressor (if available); (b) the primary transcript (pri-miRNA) is cropped into a hairpin intermediate (pre-miRNA) by the nuclear 650Â kDa microprocess complex, which consists of humans of the RNase III DROSHA (RNASEN) and the DiGeorge syndrome critical region gene 8 (DGCR8) . The step (2) defines a transport reaction to translocate the miRNA into cytoplasm so that it is ready for the following target binding process. The step (3) is a degradation process. The step (4) simplifies two processes: (a) mature miRNA binds to different protein partners and turns into the RNA-induced silencing complex (RISC); (b) RISC recognizes the target mRNA and binds to it. The steps (5), (6) and (7) are transcription, translation and degradation of target gene, mRNA and protein, respectively