The role of the REG4 gene and its encoding product in ovarian epithelial carcinoma

BMC Cancer

Table 2 Relationship between REG4 protein expression and clinicopathological features of ovarian cancers

Clinicopathological features	n	REG4 protein expression
Clinicopathological features	n	−	+	++	+++	PR (%)	P-value
Age (years)							0.03*
<56	115	63	25	15	12	45.2
≥56	120	53	20	26	21	55.8
Pathological classification							0.009**
Mucinous adenocarcinoma	26	7	6	3	10	73.1*
Serous adenocarcinoma	174	93	29	35	17	46.6
Miscellaneous subtypes	35	16	10	3	6	54.3
FIGO staging							0.485
I–II	87	47	15	10	15	46.0
III–IV	148	69	30	31	18	53.4
Differentiation							0.001***
Well-differentiated	59	21	15	11	12	64.4
Moderately-differentiated	89	39	17	19	14	56.2
Poorly-differentiated	87	56	13	11	7	35.6
Ki-67 expression							0.419
−	56	32	10	7	7	42.9
+	34	13	7	10	4	61.8
++	34	18	6	7	3	47.1
+++	33	16	7	6	4	51.5

*P < 0.05, which were pointed out by bold text, indicate statistically significant
**P < 0.01 (Mucinous adenocarcinoma compared with other pathological subtypes)
***P = 0.001 (Well- and moderately-differentiated compared with poorly-differentiated)

ISSN: 1471-2407