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Fig. 4 | BMC Cancer

Fig. 4

From: Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms

Fig. 4

ERBB2 immunohistochemical heterogeneity in two MC and sequencing results from each distinct component. ERBB2+ regions were microdissected and sequenced independently from the ERBB2- components to compare mutation events. Identical KRAS mutations were observed in the ERBB2+ and ERBB2- regions for both cases. ERBB2 high-intensity staining regions was used as a proxy for gene amplification status, as regions previously defined by this high-level IHC staining correlated perfectly with FISH and/or CISH data suggesting amplification of the ERBB2 gene [13]

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BMC Cancer

ISSN: 1471-2407

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