Table 4 Identification of potential targets from known targets of the 50 compound analogs with the highest similarity scores
From: Identification of novel drugs to target dormant micrometastases
Compound | Targets |
|---|---|
DT320 | Matrix Metalloproteinases (31)a |
Adenosine A1 receptor (7) | |
Adenosine A2 receptors (12) | |
Carbonic Anhydrases (5) | |
Protein-tyrosine phosphatase (4) | |
Unspecified (4) | |
Adenosine A3 receptor (2) | |
Dual specificity protein phosphatase 6 (2) | |
ADAM17, Aminopeptidase N, ATP-binding cassette sub-family C member 8, Beta-TC6, Glyceraldehyde-3-phosphate dehydrogenase liver, Glycogen synthase kinase-3 beta, Microbial collagenase, PARP1, (all 1) | |
DT310 | Matrix Metalloproteinases (27) |
Adenosine A1 receptor (11) | |
Adenosine A2 receptors (12) | |
Carbonic Anhydrases (5) | |
Protein-tyrosine phosphatase (4) | |
Unspecified (4) | |
Adenosine A3 receptor (2) | |
Dual specificity protein phosphatase 6 (2) | |
ADAM17, Aminopeptidase N, ATP-binding cassette | |
sub-family C member 8, Beta-TC6, Glyceraldehyde-3-phosphate dehydrogenase liver, Glycogen synthase kinase-3 beta, Microbial collagenase, PARP1, (all 1) |