Table 1 Relative potency of hits against MDA-MB-435 cells on SISgel (S) and plastic (P) and MTD vs doxorubicin
From: Identification of novel drugs to target dormant micrometastases
Designation | Chemical name, CAS number and link to structure | MW | EC50-P (μM) | EC50-S (μM) | SIa | MTD (mg/kg) |
|---|---|---|---|---|---|---|
DT310 | 4-(1-naphthalenylhydrazinylidene) -3-oxonaphthalene-2,7-disulfonic acid 5858-33-3. http://www.chemnet.com/cas/es/5858-33-3/Bordeaux%20R.html | 502 | 86.5 | 35.9 | 2.4 | 65 |
DT320 | 4,5-Dihydroxy-3-(1-naphthalenylazo)-2,7-naphthalenedisulfonic acid disodium salt 5850-63-5 http://www.chemnet.com/cas/en/5850-63-5/Pontacyl-violet.html | 518 | 78.0 | 8.7 | 9.0 | 75 |
DT340 | 10-(2,3,4-trimethoxyphenyl)-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione 669753-40-6 http://www.hit2lead.com/result.asp?search=87085397 | 417 | 219 | 117 | 1.9 | <10 |
DT350 | 2,2,4-trimethyl-1,2-dihydro-6-quinolinyl (4-methoxyphenyl)-acetate 376621-78-2 http://www.hit2lead.com/result.asp?search=43317184 | 337 | 1831 | 270 | 6.8 | <10 |
Doxorubicin | 7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione 23214-92-8 | 544 | 47.8 | 45.4 | 1.05 | 1 |