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Table 1 Patient and disease characteristics

From: Randomized phase III clinical trial comparing the combination of capecitabine and oxaliplatin (CAPOX) with the combination of 5-fluorouracil, leucovorin and oxaliplatin (modified FOLFOX6) as adjuvant therapy in patients with operated high-risk stage II or stage III colorectal cancer

 

Group A

Group B

p-value

N = 197

N = 211

Age

Median

62.4

63.7

0.45

 

Range

23.7–74.7

36.6–75.0

 

BMI

Median

26.75

26.90

0.89

 

Range

17.9–34.6

17.3–35.0

 
  

N (%)

N (%)

 

Gender

Female

86 (43.6)

94 (44.5)

0.91

 

Male

111 (56.4)

117 (55.5)

 

PS (ECOG)

0

177 (91.7)

195 (93.7)

0.37

 

1

16 (8.3)

13 (6.3)

 
 

Unknown

4

3

 

Anemia (Hb < 12g/dL)

No

148 (77.9)

161 (78.9)

0.75

 

Yes

42 (22.1)

43 (21.1)

 
 

Unknown

7

7

 

Weight loss

No

181 (94.8)

191 (93.6)

0.61

 

Yes

10 (5.2)

13 (6.4)

 
 

Unknown

6

7

 

TNM stage

II

61 (31.9)

68 (33.5)

0.66

 

T3N0

54 (88.5)

60 (88.2)

 
 

T4N0

7 (11.5)

8 (11.8)

 
 

III

130 (68.1)

135 (66.5)

 
 

TxN1

81 (62.3)

83 (61.5)

 
 

TxN2

49 (37.7)

52 (38.5)

 
 

Unknown

6

8

 

Histological grade

Grade 1

12 (6.3)

12 (5.9)

0.82

 

Grade 2

139 (72.4)

152 (74.9)

 
 

Grade 3

41 (21.3)

39 (19.2)

 
 

Unknown

5

8

 

Mucinous component

No

120 (67.8)

128 (72.7)

0.35

 

Yes

57 (32.2)

48 (27.3)

 
 

Unknown

20

35

 

Obstruction

No

167 (85.2)

179 (86.1)

0.84

 

Yes

29 (14.8)

29 (13.9)

 
 

Unknown

1

3

 

Perforation

No

181 (92.0)

190 (91.8)

0.95

 

Yes

16 (8.0)

17 (8.2)

 
 

Unknown

0

4

 

LVI/PNI (stage II)a

No

48 (80.0)

57 (85.1)

0.45

 

Yes

12 (20.0)

10 (14.9)

 
 

Unknown

1

1

 

Primary site

Right colonb

58 (29.5)

64 (30.8)

0.89

 

Left colonb

86 (43.6 %)

87 (41.8 %)

 
 

Rectum

53 (26.9 %)

57 (27.4 %)

 
 

Unknown

0

3

 
  1. BMI body mass index, PS performance status, Hb hemoglobin; Tx any T
  2. aLymphovascular and/or perineural infiltration in patients with stage II disease
  3. bRight colon: cecum, ascending colon, hepatic flexure, transverse colon; Left colon: splenic flexure, descending colon, sigmoid