Fig. 7

Association of Cell surface GRP78 with α2M* facilitated the maximal activation of EGFR in a c-Src dependent manner. (a) Western blot analysis of the expression and phosphorylation of EGFR in serum starved QGY-7703 treated with vehicle, α2M*, PP2 or PP2 in combination with α2M*. (b) Quantitative analysis of the expression and phosphorylation of EGFR in serum starved QGY-7703 treated with vehicle, α2M*, PP2 or PP2 in combination with α2M*. (c) Co-immunoprecipitation analysis of the interaction between c-Src and EGFR in serum starved QGY-7703 cells treated with vehicle, α2M*, PP2 or PP2 in combination with α2M*. (d) Quantitative analysis of the interaction between c-Src and EGFR in serum starved QGY-7703 cells treated with vehicle, α2M*, PP2 or PP2 in combination with α2M*