Table 5 Chk1 inhibitors reduced TH-302-mediated HeLa cell-cycle arrest
From: Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition
|  | TH-302 μM | TH-302 alone | TH-302+0.1 μM PF | ||||
|---|---|---|---|---|---|---|---|
%G0/G1 | %S | %G2/M | %G0/G1 | %S | %G2/M | ||
Normoxia (21% O2) | 0 | 64 | 18 | 19 | 72 | 13 | 17 |
12.5 | 65 | 11 | 24 | 65 | 13 | 23 | |
25 | 61 | 12 | 27 | 71 | 10 | 19 | |
50 | 31 | 17 | 52 | 57 | 14 | 28 | |
Hypoxia (N2) | 0.0625 | 75 | 8 | 17 | 71 | 12 | 18 |
0.125 | 68 | 8 | 24 | 76 | 8 | 16 | |
0.25 | 54 | 10 | 36 | 60 | 11 | 29 | |