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Table 3 Comparisons of the discriminatory ability of prognostic scores by comparing the AUC

From: A novel inflammation-based prognostic score in esophageal squamous cell carcinoma: the C-reactive protein/albumin ratio

Indexes AUC 95% CI Pvalue Significance of comparison §P’value
6 months of follow-up     
TNM stage (AJCC, 7th) 0.752 0.658 – 0.847 <0.001* 0.53
CRP/Alb (continuous) 0.706 0.597 – 0.815 <0.001* -
CRP/Alb (categorical) 0.702 0.604 – 0.800 <0.001* -
mGPS 0.665 0.550 – 0.781 0.003* 0.61
NLR (continuous) 0.649 0.553 – 0.745 0.007* 0.44
NLR (categorical) 0.584 0.484 – 0.683 0.132 0.09
PLR (continuous) 0.650 0.557 – 0.743 0.007* 0.45
PLR (categorical) 0.563 0.450 – 0.677 0.255 0.07
1 year of follow-up     -
TNM stage (AJCC, 7th) 0.706 0.642 – 0.771 <0.001* 0.87
CRP/Alb (continuous) 0.698 0.631 – 0.765 <0.001* -
CRP/Alb (categorical) 0.670 0.600 – 0.739 <0.001* -
mGPS 0.626 0.550 – 0.701 0.001* 0.16
NLR (continuous) 0.576 0.506 – 0.645 0.040* 0.01*
NLR (categorical) 0.552 0.482 – 0.621 0.162 0.02*
PLR (continuous) 0.584 0.509 – 0.659 0.022* 0.03*
PLR (categorical) 0.574 0.499 – 0.648 0.046* 0.06
2 years of follow-up     
TNM stage (AJCC, 7th) 0.731 0.680 – 0.783 <0.001* 0.02*
CRP/Alb (continuous) 0.638 0.579 – 0.697 <0.001* -
CRP/Alb (categorical) 0.619 0.560 – 0.679 <0.001* -
mGPS 0.574 0.513 – 0.636 0.015* 0.14
NLR (continuous) 0.555 0.496 – 0.614 0.074 0.05*
NLR (categorical) 0.550 0.491 – 0.609 0.102 0.10
PLR (continuous) 0.566 0.506 – 0.626 0.031* 0.09
PLR (categorical) 0.556 0.495 – 0.617 0.067 0.14
  1. *Significant P value of ROC curves analysis.
  2. Abbreviation: ROC receiver operating characteristics, AUC area under the curves, TNM tumor-node-metastasis, AJCC American Joint Committee on Cancer, CRP/Alb the C-reactive protein/Albumin ratio, mGPS the modified Glasgow Prognostic Score, NLR the neutrophil lymphocyte ratio, PLR the platelet lymphocyte ratio.
  3. § Comparisons of AUC values were made between the CRP/Alb ratio and other inflammation-based prognostic factors using z test method, a two tailed P value <0.05 was considered statistically significant. Significant differences were marked with “*”. Continuous indexes were compared with the CRP/Alb ratio as a continuous variable, while categorical indexes were compared with the CRP/Alb ratio as a categorical variable.