A novel inflammation-based prognostic score in esophageal squamous cell carcinoma: the C-reactive protein/albumin ratio

Table 3 Comparisons of the discriminatory ability of prognostic scores by comparing the AUC

Indexes	AUC	95% CI	Pvalue	Significance of comparison §P’value
6 months of follow-up
TNM stage (AJCC, 7th)	0.752	0.658 – 0.847	<0.001*	0.53
CRP/Alb (continuous)	0.706	0.597 – 0.815	<0.001*	-
CRP/Alb (categorical)	0.702	0.604 – 0.800	<0.001*	-
mGPS	0.665	0.550 – 0.781	0.003*	0.61
NLR (continuous)	0.649	0.553 – 0.745	0.007*	0.44
NLR (categorical)	0.584	0.484 – 0.683	0.132	0.09
PLR (continuous)	0.650	0.557 – 0.743	0.007*	0.45
PLR (categorical)	0.563	0.450 – 0.677	0.255	0.07
1 year of follow-up				-
TNM stage (AJCC, 7th)	0.706	0.642 – 0.771	<0.001*	0.87
CRP/Alb (continuous)	0.698	0.631 – 0.765	<0.001*	-
CRP/Alb (categorical)	0.670	0.600 – 0.739	<0.001*	-
mGPS	0.626	0.550 – 0.701	0.001*	0.16
NLR (continuous)	0.576	0.506 – 0.645	0.040*	0.01*
NLR (categorical)	0.552	0.482 – 0.621	0.162	0.02*
PLR (continuous)	0.584	0.509 – 0.659	0.022*	0.03*
PLR (categorical)	0.574	0.499 – 0.648	0.046*	0.06
2 years of follow-up
TNM stage (AJCC, 7th)	0.731	0.680 – 0.783	<0.001*	0.02*
CRP/Alb (continuous)	0.638	0.579 – 0.697	<0.001*	-
CRP/Alb (categorical)	0.619	0.560 – 0.679	<0.001*	-
mGPS	0.574	0.513 – 0.636	0.015*	0.14
NLR (continuous)	0.555	0.496 – 0.614	0.074	0.05*
NLR (categorical)	0.550	0.491 – 0.609	0.102	0.10
PLR (continuous)	0.566	0.506 – 0.626	0.031*	0.09
PLR (categorical)	0.556	0.495 – 0.617	0.067	0.14

*Significant P value of ROC curves analysis.
Abbreviation: ROC receiver operating characteristics, AUC area under the curves, TNM tumor-node-metastasis, AJCC American Joint Committee on Cancer, CRP/Alb the C-reactive protein/Albumin ratio, mGPS the modified Glasgow Prognostic Score, NLR the neutrophil lymphocyte ratio, PLR the platelet lymphocyte ratio.
§ Comparisons of AUC values were made between the CRP/Alb ratio and other inflammation-based prognostic factors using z test method, a two tailed P value <0.05 was considered statistically significant. Significant differences were marked with “*”. Continuous indexes were compared with the CRP/Alb ratio as a continuous variable, while categorical indexes were compared with the CRP/Alb ratio as a categorical variable.

ISSN: 1471-2407