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Table 3 Predictive factors for disease-free survival of UTUC patients after RNU

From: High expression of KPNA2 defines poor prognosis in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy

Variable Characteristics Univariate Multivariate
HR (95%CI) P value HR (95%CI) P value
Age (y) ≥70 vs <70 0.996 (0.969-1.023) 0.761   
Sex Male vs female 2.079 (1.268-3.409) 0.004 2.171 (1.340-3.516) 0.002
BMI (kg/m2) ≥25 vs <25 1.078 (0.648-1.791) 0.773   
Tumor side Left vs Right 1.293 (0.782-2.137) 0.316   
Tumor location Ureter vs Pelvis 2.243 (1.171-4.296) 0.015 1.526 (0.951-2.448) 0.080
Tumor multiplicity Multiple vs Single 1.954 (1.180-3.234) 0.009 1.820 (1.132-2.925) 0.013
Tumor size (cm) ≥3.5 vs <3.5 1.293 (0.782-2.137) 0.316   
Tumor configuration Nonpapillary vs Papillary 0.722 (0.369-1.414) 0.343   
T stage T2-T4 vs Ta-T1 2.041 (1.173-4.195) 0.012 1.836 (1.132-3.125) 0.022
G grade High vs Low 0.831 (0.471-1.467) 0.523   
eGFR (ml/min/1.73 m2) <60 vs ≥60 0.822 (0.483-1.400) 0.471   
Hydronephrosis Present vs Absent 0.552 (0.288-1.057) 0.073   
Lymph node stage N+ vs N0 1.437 (0.458-4.512) 0.535   
KPNA2 expression High vs Low 3.424 (1.972-5.944) 0.000 2.754 (1.683-4.506) 0.001
  1. HR, hazard radio; CI, confidence interval; BMI, body mass index; eGFR, estimated glomerular filtration rate.