Figure 1
From: Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis
PAK1 activation and Crk phosphorylation are correlated with loss of E-cadherin and p120-catenin in NSCLC specimens. Photomicrographs demonstrating immunohistochemical staining of NSCLC clinical specimens. Samples 12, 54, 16 and 75 harbor high E-cadherin/p120-catenin while expressing no detectable level of p-PAK1(Thr423) and p-Crk-II(Ser41). On the other hand, samples 49, 73 and 57 with detectable p-PAK1(Thr423) and p-Crk-II(Ser41) show very low levels of E-cadherin/p120-catenin.