Table 2 Fold changes in expression of known p63 target genes in response to WT1 and p63 gene knockdown in FaDu cells
Gene name | Expected effect by p63* | Fold change (vs control) | Gene function | |
|---|---|---|---|---|
siWT1 | sip63 | |||
SFN | Repressed | 0.41 | 0.38 | Cell proliferation |
Skp2 | Activated | 0.49 | 0.46 | Cell cycle |
CAD | Activated | 0.50 | 0.47 | Pyrimidine metabolism |
Fjx1 | Unspecified | 0.44 | 0.47 | Cell growth |
INPP4B | Unspecified | 1.10 | 1.27 | Inositol phosphate metabolism |
CITED2 | Activated | 1.20 | 1.67 | Cell cycle |
TGM2 | Unspecified | 2.05 | 2.08 | Cell cycle |
PLAC8 | Repressed | 2.51 | 2.43 | Cell migration |
GDF15 | Activated | 1.18 | 2.66 | Cell migration |
IGFBP3 | Repressed | 2.63 | 2.85 | Cell proliferation |