Figure 4

Effect of FGF9 on invasion and MMPs expression of gastric cancer cells. (A) Effect of FGF9 on gastric cancer cell invasion. Change in number of invasive AGS and MKN28 cells treated with FGF9 were examined. Photographs showing representative images of invasive gastric cancer cells in the control and FGF9-treated groups. (B) Effect of anti-FGF9 neutralizing antibody (Neu Ab; 1 μg/ml) on FGF9 (10 ng/ml)-induced invasion of AGS and MKN28 cells. (C) Effect of FGF9 on expression of MMPs in gastric cancer cells. All the results are expressed as the mean ± SD of four samples. Significantly greater than control: *P <0.05, **P <0.01. Significantly lower than the FGF9-treated group: ^#P <0.05, ^##P <0.01.