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Table 1 Differentially regulated plasma membrane proteins identified in GC tissues

From: Plasma membrane proteomic analysis of human Gastric Cancer tissues: revealing flotillin 1 as a marker for Gastric Cancer

Accession No. Gene symbols Description TMT ratio P value Function
Q12959 DLG1 discs, large homolog 1 (Drosophila) -8.78 1.28E-05 kinase
G8JLH6 CD9 CD9 molecule -3.723 7.04E-02 other
P30453 HLA-A major histocompatibility complex, class I, A -2.903 7.40E-04 other
O95810 SDPR serum deprivation response -2.623 1.69E-09 other
P48960 CD97 CD97 molecule -2.615 3.74E-01 G-protein coupled receptor
Q16853 AOC3 amine oxidase, copper containing 3 -2.314 1.11E-10 enzyme
E7EWP3 MPZ myelin protein zero -2.266 2.45E-07 other
Q03135 CAV1 caveolin 1, caveolae protein, 22 kDa -2.251 2.43E-10 transmembrane receptor
P41219 PRPH peripherin -2.149 1.65E-08 other
P43121 MCAM melanoma cell adhesion molecule -2.115 1.93E-09 other
Q9HAV0 GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -1.976 9.69E-04 enzyme
Q86UP2 KTN1 kinectin 1 (kinesin receptor) -1.959 7.69E-03 transmembrane receptor
P01859 IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker) -1.844 1.43E-02 other
B7Z2R4 SGCE sarcoglycan, epsilon -1.791 2.91E-02 other
P18206 VCL vinculin -1.685 2.01E-10 enzyme
A0FGR8 ESYT2 extended synaptotagmin-like protein 2 -1.672 2.68E-03 other
P08133 ANXA6 annexin A6 -1.668 1.10E-11 ion channel
O43491 EPB41L2 erythrocyte membrane protein band 4.1-like 2 -1.66 1.05E-08 other
Q14BN4 SLMAP sarcolemma associated protein -1.645 6.33E-04 other
A6NMH8 CD81 CD81 molecule -1.634 3.17E-04 other
Q96CX2 KCTD12 potassium channel tetramerization domain containing 12 -1.559 3.59E-08 ion channel
Q9H223 EHD4 EH-domain containing 4 -1.527 1.30E-03 enzyme
Q13418 ILK integrin-linked kinase -1.526 1.20E-09 kinase
P16671 CD36 CD36 molecule (thrombospondin receptor) -1.501 1.16E-06 transmembrane receptor
P38606 ATP6V1A ATPase, H+ transporting, lysosomal 70 kDa, V1 subunit A 1.514 3.79E-05 transporter
Q14108 SCARB2 scavenger receptor class B, member 2 1.514 1.92E-08 other
P01903 HLA-DRA major histocompatibility complex, class II, DR alpha 1.521 2.94E-08 transmembrane receptor
Q14444 CAPRIN1 cell cycle associated protein 1 1.529 1.30E-06 other
Q6IAA8 LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 1.533 5.18E-03 other
P27216 ANXA13 annexin A13 1.536 3.38E-09 other
Q9Y287 ITM2B integral membrane protein 2B 1.553 7.16E-02 other
Q9Y6R1 SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 1.558 2.21E-04 transporter
Q8WVV4 POF1B premature ovarian failure, 1B 1.568 9.94E-09 other
D6RH31 NPNT nephronectin 1.59 1.40E-05 other
Q9P0L0 VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33 kDa 1.597 7.50E-06 other
P02786 TFRC transferrin receptor 1.602 3.53E-01 transporter
O00203 AP3B1 adaptor-related protein complex 3, beta 1 subunit 1.619 5.16E-03 transporter
Q00610 CLTC clathrin, heavy chain (Hc) 1.623 6.18E-11 other
P26006 ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 1.645 3.24E-08 other
O95292 VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 1.652 4.17E-05 other
B4DNJ6 STRAP serine/threonine kinase receptor associated protein 1.654 4.56E-03 other
B5MCA4 EPCAM epithelial cell adhesion molecule 1.655 4.47E-03 other
Q14247 CTTN cortactin 1.664 2.58E-06 other
C9JME2 FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 1.667 4.07E-10 other
P15144 ANPEP alanyl (membrane) aminopeptidase 1.693 7.85E-10 peptidase
G5EA09 SDCBP syndecan binding protein (syntenin) 1.71 1.01E-06 enzyme
O75955 FLOT1 flotillin 1 1.727 2.09E-02 other
Q86XK7 VSIG1 V-set and immunoglobulin domain containing 1 1.727 1.27E-04 other
P00533 EGFR epidermal growth factor receptor 1.755 2.27E-01 kinase
P17301 ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 1.786 1.19E-08 transmembrane receptor
P29992 GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 1.786 7.56E-02 enzyme
C9J6P4 ZC3HAV1 zinc finger CCCH-type, antiviral 1 1.835 3.35E-09 other
P27105 STOM stomatin 1.844 1.31E-04 other
P46977 STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 1.895 5.89E-05 enzyme
Q9BX66 SORBS1 sorbin and SH3 domain containing 1 1.895 1.62E-08 other
O95563 MPC2 mitochondrial pyruvate carrier 2 1.917 2.32E-08 other
P09496 CLTA clathrin, light chain A 1.926 1.13E-12 other
Q13155 AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 1.928 1.03E-07 other
P09497 CLTB clathrin, light chain B 1.954 1.00E-10 other
H9KV28 DIAPH1 diaphanous-related formin 1 1.958 8.62E-04 other
Q99720 SIGMAR1 sigma non-opioid intracellular receptor 1 1.961 3.62E-04 G-protein coupled receptor
P13473 LAMP2 lysosomal-associated membrane protein 2 1.999 5.05E-10 enzyme
F5H7K4 NCEH1 neutral cholesterol ester hydrolase 1 2.006 5.68E-04 enzyme
P11215 ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.012 2.29E-10 transmembrane receptor
P15924 DSP desmoplakin 2.031 8.86E-13 other
Q9UGM3 DMBT1 deleted in malignant brain tumors 1 2.079 2.59E-06 transmembrane receptor
Q93008 USP9X ubiquitin specific peptidase 9, X-linked 2.19 1.22E-01 peptidase
O15400 STX7 syntaxin 7 2.208 1.94E-07 transporter
Q9BXJ0 C1QTNF5 C1q and tumor necrosis factor related protein 5 2.223 2.33E-04 transmembrane receptor
Q9UJZ1 STOML2 stomatin (EPB72)-like 2 2.228 1.06E-04 other
P55011 SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 2.332 5.91E-11 transporter
O00182 LGALS9 lectin, galactoside-binding, soluble, 9 2.45 1.39E-05 other
Q08380 LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 2.469 4.66E-06 transmembrane receptor
Q9UGI8 TES testis derived transcript (3 LIM domains) 2.577 1.55E-06 other
Q9NZ01 TECR trans-2,3-enoyl-CoA reductase 2.83 1.45E-07 enzyme
G3V1K3 PON2 paraoxonase 2 2.932 3.93E-06 enzyme
O95841 ANGPTL1 angiopoietin-like 1 3.109 4.33E-04 other
Q92542 NCSTN nicastrin 3.634 3.58E-02 peptidase
O95497 VNN1 vanin 1 3.718 1.00E-08 enzyme
P16144 ITGB4 integrin, beta 4 3.792 2.40E-01 transmembrane receptor
Q96HR9 REEP6 receptor accessory protein 6 3.797 2.70E-08 other
P48230 TM4SF4 transmembrane 4 L six family member 4 4.71 1.42E-04 other