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Table 3 Preoperative CRT versus preoperative CT

From: Neoadjuvant chemoradiation therapy for resectable esophago-gastric adenocarcinoma: a meta-analysis of randomized clinical trials

Study and year Sample size Treatment approach Treatment schedule 3 y or 5 y OS (CRT V. CT + S)
Stahl, [33] 119 CRT-Surgery V. CT-Surgery Scheme of CRT: GTV30Gy/15f cisplatin (50 mg/m2), etoposide (80 mg/m2) 3y: 52% V. 49%
Scheme of CT: 5-Fu (2 g/m2) leucovorin (500 mg/m2) cisplatin (50 mg/m2) 5y: 45% V. 36%
Burmeister, [32] 75 CRT-Surgery V. CT-Surgery Scheme of CRT: Cisplatin (80 mg/m2) 5-Fu (1000 mg/m2/d) GTV35Gy/15f 3y: 47.4% V. 27.7%
5y: NM
Scheme of CT: Cisplatin(80 mg/m2) 5-Fu (1000 mg/m2/d)
  1. Note: OS: overall survival; CRT: preoperative chemoradiation therapy; CT: preoperative chemotherapy; V: versus; Surg: surgery; 5-Fu: fluorouracil; NM: not mentioned.