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Table 4 Virological status, H-scores for stathmin, pS6, pMTOR and pAKT and clinical outcome in terms of having achieved disease stabilization of individual patient’s tumour

From: Phase I/II study of temsirolimus for patients with unresectable Hepatocellular Carcinoma (HCC)- a correlative study to explore potential biomarkers for response

Patient no. HBV/HCV/ Non-B non-C Stathmin pS6 pMTOR pAkt Disease stabilization
PW004 HBV High Low Low High No
PW005 HBV High High Low High No
PW014 HBV Low High Low Low No
PW018 HBV High Low Low Low No
PW019 HBV Low High Low Low No
PW020 Non-B, Non C Low High Low High No
PW023 HCV High Low High Low No
PW024 HBV High High Low High No
PW025 HBV High Low Low High No
PW028 HBV High Low Low High No
PW029 Non-B, Non C Low Low Low Low No
PW030 HBV High Low Low Low No
PW031 HBV High Low Low Low No
PW032 HBV High High Low Low No
PW034 HBV High High Low High No
PW035 Non-B, Non C Low Low High Low No
PW036 HBV Low High High Low No
PW039 HBV High Low Low Low No
PW040 Non-B, Non C High High Low Low No
PW042 HBV High Low Low Low No
PW015 HBV High High High Low Yes
PW016 HBV High High Low Low Yes
PW017 Non-B, Non C Low Low Low Low Yes
PW021 HBV Low Low High Low Yes
PW022 Non-B, Non C Low Low High Low Yes
PW026 HBV Low Low Low Low Yes
PW027 HBV High High Low High Yes
PW033 HBV High Low High High Yes
PW037 HBV Low High High Low Yes
PW038 HBV High High Low Low Yes
PW043 HBV High High High High Yes
PW044 HBV Low Low Low Low Yes
PW045 HBV Low High High High Yes
PW046 HBV High High Low Low Yes
  1. HBV- hepatitis B virus, HCV- hepatitis C virus, Non-B non-C- negative for hepatitis B or C.
  2. Disease stabilization rate = (CR + PR + SD) >12 weeks.