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Table 2 Univariate and multivariate analyses of factors affecting locoregional recurrence-free survival and overall survival (all patients, N = 357)

From: The emerging outcome of postoperative radiotherapy for stage IIIA(N2) non-small cell lung cancer patients: based on the three-dimensional conformal radiotherapy technique and institutional standard clinical target volume

Characteristics No. Locoregional recurrence-free survival Overall survival
Univariable Multivariate Univariable Multivariate
5-y (%) P HR (95% CI) P 5-y (%) P HR (95% CI) P
Age (yr)    0.69   0.99   0.07   0.4
 ≤60 208 73.3   1   40.0   1  
 >60 149 70.0 1.0 (0.6-1.6) 37.6 1.2 (0.8-1.6)
Gender    <0.001   0.57   <0.001   <0.001
 Male 219 64.3   1   32.5   1  
 Female 138 83.4 0.8 (0.4-1.7) 50.7 0.5 (0.3-0.7)
Smoking history    <0.001   <0.001   0.008   0.37
 Never/light 180 82.6   1   39.9   1  
 Current/heavy 177 60.9 2.6 (1.6-4.4) 36.0 0.8 (0.5-1.3)
Clinical N status    0.002   0.04   0.003   0.27
 cN0,1 193 80.4   1   50.4   1  
 cN2 164 61.4 1.7 (1.0-2.7) 26.5 1.2 (0.9-1.7)
Pathologic T stage    0.11   0.6   0.18   0.77
 pT1 80 81.4   1   45.4   1  
 pT2 239 70.7 1.0 (0.5-1.9) 39.9 0.9 (0.6-1.4)
 pT3 38 59.1 1.4 (0.6-3.1) 21.8 1.1 (0.6-1.9)
Type of surgery    0.6   0.26   <0.001   0.24
 Lobectomy 323 72.7   1   42.8   1  
 Pneumonectomy 34 65.6 0.6 (0.3-1.4) 12.8 1.3 (0.8-2.2)
Histology    0.01   0.23   0.018   0.05
 Non-squamous 257 76.7   1   44.3   1  
 Squamous 100 59.4 1.4 (0.8-2.3) 28.1 1.4 (1.0-2.0)
N of positive nodes    0.002   0.48   <0.001   0.68
 ≤4 192 80.9   1   53.2   1  
 >4 165 60.8 1.3 (0.6-2.7) 21.9 1.1 (0.7-1.9)
LNR    0.003   0.001   <0.001   <0.001
 ≤20% 172 81.5   1   55.5   1  
 >20% 185 62.7 2.3 (1.4-3.7) 24.7 2.4 (1.7-3.3)
Involved N2 stations    0.1   0.75   <0.001   0.12
 Single 177 76.1   1   56.0   1  
 Multiple 180 68.0 0.9 (0.5-1.6) 23.3 1.4 (0.9-2.0)
Cycles of POCT    0.9   0.79   0.001   <0.001
 <4 90 69.5   1   29.8   1  
 ≥4 267 72.7 1.1 (0.6-1.9) 41.3 0.5 (0.3-0.7)
PORT    <0.001   0.001   0.003   0.001
 No 287 66.4   1   35.1   1  
 Yes 70 91.9   0.2 (0.1-0.5)   57.5   0.4 (0.2-0.7)  
  1. Abbreviations: LNR = lymph node ratio, PORT = postoperative radiotherapy, POCT = postoperative chemotherapy, HR = hazard ratio, CI = confidence interval.