|
Characteristics
|
No.
|
Locoregional recurrence-free survival
|
Overall survival
|
|---|
|
Univariable
|
Multivariate
|
Univariable
|
Multivariate
|
|---|
|
5-y (%)
|
P
|
HR (95% CI)
|
P
|
5-y (%)
|
P
|
HR (95% CI)
|
P
|
|---|
|
Age (yr)
| | |
0.69
| |
0.99
| |
0.07
| |
0.4
|
|
≤60
|
208
|
73.3
| |
1
| |
40.0
| |
1
| |
|
>60
|
149
|
70.0
|
1.0 (0.6-1.6)
|
37.6
|
1.2 (0.8-1.6)
|
|
Gender
| | |
<0.001
| |
0.57
| |
<0.001
| |
<0.001
|
|
Male
|
219
|
64.3
| |
1
| |
32.5
| |
1
| |
|
Female
|
138
|
83.4
|
0.8 (0.4-1.7)
|
50.7
|
0.5 (0.3-0.7)
|
|
Smoking history
| | |
<0.001
| |
<0.001
| |
0.008
| |
0.37
|
|
Never/light
|
180
|
82.6
| |
1
| |
39.9
| |
1
| |
|
Current/heavy
|
177
|
60.9
|
2.6 (1.6-4.4)
|
36.0
|
0.8 (0.5-1.3)
|
|
Clinical N status
| | |
0.002
| |
0.04
| |
0.003
| |
0.27
|
|
cN0,1
|
193
|
80.4
| |
1
| |
50.4
| |
1
| |
|
cN2
|
164
|
61.4
|
1.7 (1.0-2.7)
|
26.5
|
1.2 (0.9-1.7)
|
|
Pathologic T stage
| | |
0.11
| |
0.6
| |
0.18
| |
0.77
|
|
pT1
|
80
|
81.4
| |
1
| |
45.4
| |
1
| |
|
pT2
|
239
|
70.7
|
1.0 (0.5-1.9)
|
39.9
|
0.9 (0.6-1.4)
|
|
pT3
|
38
|
59.1
|
1.4 (0.6-3.1)
|
21.8
|
1.1 (0.6-1.9)
|
|
Type of surgery
| | |
0.6
| |
0.26
| |
<0.001
| |
0.24
|
|
Lobectomy
|
323
|
72.7
| |
1
| |
42.8
| |
1
| |
|
Pneumonectomy
|
34
|
65.6
|
0.6 (0.3-1.4)
|
12.8
|
1.3 (0.8-2.2)
|
|
Histology
| | |
0.01
| |
0.23
| |
0.018
| |
0.05
|
|
Non-squamous
|
257
|
76.7
| |
1
| |
44.3
| |
1
| |
|
Squamous
|
100
|
59.4
|
1.4 (0.8-2.3)
|
28.1
|
1.4 (1.0-2.0)
|
|
N of positive nodes
| | |
0.002
| |
0.48
| |
<0.001
| |
0.68
|
|
≤4
|
192
|
80.9
| |
1
| |
53.2
| |
1
| |
|
>4
|
165
|
60.8
|
1.3 (0.6-2.7)
|
21.9
|
1.1 (0.7-1.9)
|
|
LNR
| | |
0.003
| |
0.001
| |
<0.001
| |
<0.001
|
|
≤20%
|
172
|
81.5
| |
1
| |
55.5
| |
1
| |
|
>20%
|
185
|
62.7
|
2.3 (1.4-3.7)
|
24.7
|
2.4 (1.7-3.3)
|
|
Involved N2 stations
| | |
0.1
| |
0.75
| |
<0.001
| |
0.12
|
|
Single
|
177
|
76.1
| |
1
| |
56.0
| |
1
| |
|
Multiple
|
180
|
68.0
|
0.9 (0.5-1.6)
|
23.3
|
1.4 (0.9-2.0)
|
|
Cycles of POCT
| | |
0.9
| |
0.79
| |
0.001
| |
<0.001
|
|
<4
|
90
|
69.5
| |
1
| |
29.8
| |
1
| |
|
≥4
|
267
|
72.7
|
1.1 (0.6-1.9)
|
41.3
|
0.5 (0.3-0.7)
|
|
PORT
| | |
<0.001
| |
0.001
| |
0.003
| |
0.001
|
|
No
|
287
|
66.4
| |
1
| |
35.1
| |
1
| |
|
Yes
|
70
|
91.9
| |
0.2 (0.1-0.5)
| |
57.5
| |
0.4 (0.2-0.7)
| |
- Abbreviations: LNR = lymph node ratio, PORT = postoperative radiotherapy, POCT = postoperative chemotherapy, HR = hazard ratio, CI = confidence interval.
