Characteristics | No. | Locoregional recurrence-free survival | Overall survival | ||||||
---|---|---|---|---|---|---|---|---|---|
Univariable | Multivariate | Univariable | Multivariate | ||||||
5-y (%) | P | HR (95% CI) | P | 5-y (%) | P | HR (95% CI) | P | ||
Age (yr) | Â | Â | 0.69 | Â | 0.99 | Â | 0.07 | Â | 0.4 |
 ≤60 | 208 | 73.3 |  | 1 |  | 40.0 |  | 1 |  |
 >60 | 149 | 70.0 | 1.0 (0.6-1.6) | 37.6 | 1.2 (0.8-1.6) | ||||
Gender | Â | Â | <0.001 | Â | 0.57 | Â | <0.001 | Â | <0.001 |
 Male | 219 | 64.3 |  | 1 |  | 32.5 |  | 1 |  |
 Female | 138 | 83.4 | 0.8 (0.4-1.7) | 50.7 | 0.5 (0.3-0.7) | ||||
Smoking history | Â | Â | <0.001 | Â | <0.001 | Â | 0.008 | Â | 0.37 |
 Never/light | 180 | 82.6 |  | 1 |  | 39.9 |  | 1 |  |
 Current/heavy | 177 | 60.9 | 2.6 (1.6-4.4) | 36.0 | 0.8 (0.5-1.3) | ||||
Clinical N status | Â | Â | 0.002 | Â | 0.04 | Â | 0.003 | Â | 0.27 |
 cN0,1 | 193 | 80.4 |  | 1 |  | 50.4 |  | 1 |  |
 cN2 | 164 | 61.4 | 1.7 (1.0-2.7) | 26.5 | 1.2 (0.9-1.7) | ||||
Pathologic T stage | Â | Â | 0.11 | Â | 0.6 | Â | 0.18 | Â | 0.77 |
 pT1 | 80 | 81.4 |  | 1 |  | 45.4 |  | 1 |  |
 pT2 | 239 | 70.7 | 1.0 (0.5-1.9) | 39.9 | 0.9 (0.6-1.4) | ||||
 pT3 | 38 | 59.1 | 1.4 (0.6-3.1) | 21.8 | 1.1 (0.6-1.9) | ||||
Type of surgery | Â | Â | 0.6 | Â | 0.26 | Â | <0.001 | Â | 0.24 |
 Lobectomy | 323 | 72.7 |  | 1 |  | 42.8 |  | 1 |  |
 Pneumonectomy | 34 | 65.6 | 0.6 (0.3-1.4) | 12.8 | 1.3 (0.8-2.2) | ||||
Histology | Â | Â | 0.01 | Â | 0.23 | Â | 0.018 | Â | 0.05 |
 Non-squamous | 257 | 76.7 |  | 1 |  | 44.3 |  | 1 |  |
 Squamous | 100 | 59.4 | 1.4 (0.8-2.3) | 28.1 | 1.4 (1.0-2.0) | ||||
N of positive nodes | Â | Â | 0.002 | Â | 0.48 | Â | <0.001 | Â | 0.68 |
 ≤4 | 192 | 80.9 |  | 1 |  | 53.2 |  | 1 |  |
 >4 | 165 | 60.8 | 1.3 (0.6-2.7) | 21.9 | 1.1 (0.7-1.9) | ||||
LNR | Â | Â | 0.003 | Â | 0.001 | Â | <0.001 | Â | <0.001 |
 ≤20% | 172 | 81.5 |  | 1 |  | 55.5 |  | 1 |  |
 >20% | 185 | 62.7 | 2.3 (1.4-3.7) | 24.7 | 2.4 (1.7-3.3) | ||||
Involved N2 stations | Â | Â | 0.1 | Â | 0.75 | Â | <0.001 | Â | 0.12 |
 Single | 177 | 76.1 |  | 1 |  | 56.0 |  | 1 |  |
 Multiple | 180 | 68.0 | 0.9 (0.5-1.6) | 23.3 | 1.4 (0.9-2.0) | ||||
Cycles of POCT | Â | Â | 0.9 | Â | 0.79 | Â | 0.001 | Â | <0.001 |
 <4 | 90 | 69.5 |  | 1 |  | 29.8 |  | 1 |  |
 ≥4 | 267 | 72.7 | 1.1 (0.6-1.9) | 41.3 | 0.5 (0.3-0.7) | ||||
PORT | Â | Â | <0.001 | Â | 0.001 | Â | 0.003 | Â | 0.001 |
 No | 287 | 66.4 |  | 1 |  | 35.1 |  | 1 |  |
 Yes | 70 | 91.9 |  | 0.2 (0.1-0.5) |  | 57.5 |  | 0.4 (0.2-0.7) |  |