Table 2 Univariate and multivariate analyses of factors affecting locoregional recurrence-free survival and overall survival (all patients, N = 357)

Age (yr)

0.69

0.99

0.07

0.4

 ≤60

208

73.3

1

40.0

1

 >60

149

70.0

1.0 (0.6-1.6)

37.6

1.2 (0.8-1.6)

Gender

<0.001

0.57

<0.001

<0.001

 Male

219

64.3

1

32.5

1

 Female

138

83.4

0.8 (0.4-1.7)

50.7

0.5 (0.3-0.7)

Smoking history

<0.001

<0.001

0.008

0.37

 Never/light

180

82.6

1

39.9

1

 Current/heavy

177

60.9

2.6 (1.6-4.4)

36.0

0.8 (0.5-1.3)

Clinical N status

0.002

0.04

0.003

0.27

 cN0,1

193

80.4

1

50.4

1

 cN2

164

61.4

1.7 (1.0-2.7)

26.5

1.2 (0.9-1.7)

Pathologic T stage

0.11

0.6

0.18

0.77

 pT1

80

81.4

1

45.4

1

 pT2

239

70.7

1.0 (0.5-1.9)

39.9

0.9 (0.6-1.4)

 pT3

38

59.1

1.4 (0.6-3.1)

21.8

1.1 (0.6-1.9)

Type of surgery

0.6

0.26

<0.001

0.24

 Lobectomy

323

72.7

1

42.8

1

 Pneumonectomy

34

65.6

0.6 (0.3-1.4)

12.8

1.3 (0.8-2.2)

Histology

0.01

0.23

0.018

0.05

 Non-squamous

257

76.7

1

44.3

1

 Squamous

100

59.4

1.4 (0.8-2.3)

28.1

1.4 (1.0-2.0)

N of positive nodes

0.002

0.48

<0.001

0.68

 ≤4

192

80.9

1

53.2

1

 >4

165

60.8

1.3 (0.6-2.7)

21.9

1.1 (0.7-1.9)

LNR

0.003

0.001

<0.001

<0.001

 ≤20%

172

81.5

1

55.5

1

 >20%

185

62.7

2.3 (1.4-3.7)

24.7

2.4 (1.7-3.3)

Involved N2 stations

0.1

0.75

<0.001

0.12

 Single

177

76.1

1

56.0

1

 Multiple

180

68.0

0.9 (0.5-1.6)

23.3

1.4 (0.9-2.0)

Cycles of POCT

0.9

0.79

0.001

<0.001

 <4

90

69.5

1

29.8

1

 ≥4

267

72.7

1.1 (0.6-1.9)

41.3

0.5 (0.3-0.7)

PORT

<0.001

0.001

0.003

0.001

 No

287

66.4

1

35.1

1

 Yes

70

91.9

0.2 (0.1-0.5)

57.5

0.4 (0.2-0.7)