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Figure 10 | BMC Cancer

Figure 10

From: Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer

Figure 10

Effects of curcumin or/and 5-FU on proliferation-, invasion-, metastatic gene products and NF-κB expression in HCT116 and HCT116R cells in alginate culture. Curcumin increases 5-FU to inhibit the expression of NF-κB and NF-κB-regulated gene products in HCT116 (A) and HCT116R (B) cells encapsulated in alginate beads. Decreased expression of CXCR4, MMP9 and NF-κB in alginate beads after 14 days of culture was confirmed by quantitative densitometry. Western blots shown are representative of three independent experiments. The housekeeping protein β-actin served as a positive loading control in all experiments. Values were compared with the control and statistically significant values with p < 0.05 were designated by an asterisk (*).

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