Table 2 Genes identified as broken in OGCTs
Chr | Gene | Function & Implication in cancer if known | Ref |
|---|---|---|---|
8 | C8orf34 | cAMP-dependent protein kinase regulator. Associated with irinotecan-related toxicities in patients with non-small-cell lung cancer. | [60] |
18 | CELF4 | CELF/BRUNOL protein, alternative splicing factor. When lost, independent prognostic indicator in colorectal cancer. | [61] |
14 | NPAS3 | Basic helix-loop-helix and PAS domain-containing transcription factor, tumor suppressor in astrocytomas | [62] |
15 | SPG11 | Potential transmembrane protein phosphorylated upon DNA damage. Mutated in recessive hereditary spastic paraplegia. | [63] |
21 | RUNX1 | CBF transcription factor subunit. Tumor suppressor, with oncogenic fusions in leukemias and mutations in breast cancers. | [64] |