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Table 2 Genes identified as broken in OGCTs

From: Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes

Chr Gene Function & Implication in cancer if known Ref
8 C8orf34 cAMP-dependent protein kinase regulator. Associated with irinotecan-related toxicities in patients with non-small-cell lung cancer. [60]
18 CELF4 CELF/BRUNOL protein, alternative splicing factor. When lost, independent prognostic indicator in colorectal cancer. [61]
14 NPAS3 Basic helix-loop-helix and PAS domain-containing transcription factor, tumor suppressor in astrocytomas [62]
15 SPG11 Potential transmembrane protein phosphorylated upon DNA damage. Mutated in recessive hereditary spastic paraplegia. [63]
21 RUNX1 CBF transcription factor subunit. Tumor suppressor, with oncogenic fusions in leukemias and mutations in breast cancers. [64]