Figure 4
From: Frequency and distribution of Notch mutations in tumor cell lines
Notch receptors constitute mutational hot spots in cancer cell lines. (A-H) Mutation frequencies of NOTCH1-4 (A) and proteins that are well known in the pathology of cancer (B-E), as well as house-keeping proteins that do not have an established role in tumor formation (F-H). Mutation frequencies are shown for both cancer cell lines and primary tumors for 12 different cell types, as indicated. In (I), the difference in percentage (∆%) between cell lines and primary tumors for each protein/protein family in (A-H), and for each cell type have been ranked and plotted. Values have been normalized to the average coding region size of each protein/protein family (∆%/10000 bp).