Table 1 Patient characteristics and clinicopathological features according to RAS mutations
Characteristics | All patients | AllRASWT | KRASexon2 MT | Any otherRASMTa | Pvalue | |
|---|---|---|---|---|---|---|
(n= 264, %) | (n= 153, %) | (n= 90, %) | (n= 21, %) | |||
Age | Median (range) | 64 (32–86) | 64 (32–82) | 64 (38–82) | 68 (48–86) | 0.32* |
Gender | Male | 166 (62.9) | 94 (61.4) | 56 (62.2) | 16 (76.2) | 0.41** |
Primary lesion | Right-sided colon | 53 (20.1) | 29 (19.0) | 21 (23.3) | 3 (14.3) | 0.08** |
Left-sided colon | 70 (26.5) | 50 (32.7) | 15 (16.7) | 5 (23.8) | Â | |
Rectum | 141 (53.4) | 74 (48.3) | 54 (60.0) | 13 (61.9) | Â | |
Histology | Well, mod | 240 (90.9) | 133 (86.9) | 88 (97.8) | 19 (90.5) | 0.17** |
Por, muc | 24 (9.1) | 20 (13.1) | 2 (2.2) | 2 (9.5) | Â | |
Site of metastasis | Liver | 137 (51.2) | 73 (47.7) | 49 (54.4) | 15 (71.4) | 0.10** |
Lung | 100 (37.9) | 55 (35.9) | 40 (44.4) | 5 (23.8) | 0.16** | |
Lymph node | 150 (56.8) | 87 (56.9) | 49 (54.4) | 14 (66.7) | 0.59** | |
Peritoneum | 52 (19.7) | 33 (21.6) | 15 (16.7) | 4 (19.0) | 0.64** | |