Figure 1

Summary of RNA-Seq analysis of CCA tumor tissue and controls. A. Mapping of short-reads to the human genome showed an enrichment of miRNA species versus protein coding genes and other small non-coding RNA species; B. Top ten significantly (BH corrected p < 0.05) up- and down-regulated miRNAs after differential expression analysis of tumor tissue and matched distal normal tissue. FC; Fold change, FDR; Benjamini and Hochberg corrected p value; C. Linear regression analysis (solid line) of miRNA fold changes in tumor tissue versus matched distal normal tissue (D-NT) and non-CCA normal liver tissue (N NT). Plot is annotated with the regression equation.