From: Association of high obesity with PAM50 breast cancer intrinsic subtypes and gene expression
 | Total n | PAM50 Intrinsic Subtype - Overalla | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Luminal A | Luminal B | Basal-like | HER2-E | Normal-like | |||||||||
 | % | % | OR | 95% CI | % | OR | 95% CI | % | OR | 95% CI | % | OR | 95% CI | |
BMI (kg/m 2 ) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Underweight (<18.5) | 13 | 0.4 | 1.0 | 0.56 | 0.07, 4.79 | 1.2 | 7.44 | 2.03, 27.32 | 0.2 | 0.73 | 0.09, 5.93 | 0.0 | Not calculable | |
Normal weight (18.5-24.9) | 658 | 43.0 | 34.0 | Ref | Â | 30.6 | Ref | Â | 41.3 | Ref | Â | 41.3 | Ref | Â |
Overweight (25.0-29.9) | 509 | 28.6 | 34.1 | 1.72 | 1.10, 2.71 | 28.8 | 1.71 | 1.13, 2.61 | 29.6 | 1.07 | 0.69, 1.64 | 33.8 | 1.13 | 0.42, 3.05 |
Mildly Obese (30.0-34.9) | 290 | 20.8 | 17.0 | 1.14 | 0.67, 1.95 | 19.4 | 1.38 | 0.81, 2.36 | 15.3 | 0.72 | 0.41, 1.29 | 21.5 | 1.10 | 0.35, 3.51 |
Highly Obese (≥35.0) | 206 | 7.6 | 13.9 | 2.44 | 1.24, 4.79 | 20.0 | 3.75 | 1.97, 7.12 | 13.5 | 1.97 | 0.99, 3.89 | 3.4 | 0.45 | 0.11, 1.85 |
 | Total n | PAM50 Intrinsic Subtype - Premenopausal a,b | ||||||||||||
 | Luminal A | Luminal B | Basal-like | HER2-E | Normal-like | |||||||||
 | % | % | OR | 95% CI | % | OR | 95% CI | % | OR | 95% CI | % | OR | 95% CI | |
BMI (kg/m 2 ) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Underweight (<18.5) | 5 | 0.3 | 2.7 | Not calculable | 1.6 | 9.70 | 1.22, 77.39 | 1.0 | 3.83 | 0.36, 41.95 | 0.0 | Not calculable | ||
Normal weight (18.5-24.9) | 179 | 41.3 | 40.6 | Ref | Â | 36.3 | Ref | Â | 46.9 | Ref | Â | 19.9 | Ref | Â |
Overweight (25.0-29.9) | 112 | 27.2 | 33.7 | 1.77 | 0.69, 4.52 | 27.4 | 1.20 | 0.52, 2.79 | 22.3 | 0.87 | 0.35, 2.16 | 26.7 | 2.96 | 0.41, 21.51 |
Mildly Obese (30.0-34.9) | 82 | 22.5 | 17.0 | 0.85 | 0.31, 2.32 | 20.2 | 0.74 | 0.31, 1.79 | 14.5 | 0.50 | 0.18, 1.38 | 45.4 | 4.00 | 0.63, 25.42 |
Highly Obese (≥35.0) | 50 | 9.0 | 6.0 | 0.97 | 0.21, 4.49 | 14.5 | 1.31 | 0.43, 4.03 | 15.2 | 1.92 | 0.53, 6.96 | 8.0 | 2.21 | 0.28, 17.67 |
 | Total n | PAM50 Intrinsic Subtype - Postmenopausal a,b | ||||||||||||
 | Luminal A | Luminal B | Basal-like | HER2-E | Normal-like | |||||||||
 | % | % | OR | 95% CI | % | OR | 95% CI | % | OR | 95% CI | % | OR | 95% CI | |
BMI (kg/m 2 ) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Underweight (<18.5) | 8 | 0.4 | 0.2 | 0.82 | 0.10, 6.62 | 1.1 | 6.97 | 1.09, 44.38 | 0.0 | Not calculable | 0.0 | Not calculable | ||
Normal weight (18.5-24.9) | 427 | 41.9 | 30.9 | Ref | Â | 26.8 | Ref | Â | 39.4 | Ref | Â | 44.1 | Ref | Â |
Overweight (25.0-29.9) | 364 | 29.4 | 34.4 | 1.79 | 1.04, 3.08 | 29.0 | 1.94 | 1.13, 3.34 | 30.3 | 1.08 | 0.65, 1.82 | 38.6 | 1.20 | 0.39, 3.63 |
Mildly Obese (30.0-34.9) | 195 | 21.6 | 16.5 | 1.07 | 0.56, 2.05 | 18.8 | 1.59 | 0.74, 3.43 | 16.7 | 0.77 | 0.38, 1.56 | 14.9 | 0.73 | 0.19, 2.75 |
Highly Obese (≥35.0) | 141 | 7.2 | 18.0 | 3.10 | 1.44, 6.68 | 24.3 | 6.12 | 2.81, 13.35 | 13.6 | 2.01 | 0.90, 4.48 | 2.4 | 0.29 | 0.04, 1.83 |