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Table 4 Association of BMI around breast cancer diagnosis with PAM50 intrinsic subtype, overall and by menopausal status

From: Association of high obesity with PAM50 breast cancer intrinsic subtypes and gene expression

 

Total n

PAM50 Intrinsic Subtype - Overalla

 

Luminal A

Luminal B

Basal-like

HER2-E

Normal-like

 

%

%

OR

95% CI

%

OR

95% CI

%

OR

95% CI

%

OR

95% CI

BMI (kg/m 2 )

              

Underweight (<18.5)

13

0.4

1.0

0.56

0.07, 4.79

1.2

7.44

2.03, 27.32

0.2

0.73

0.09, 5.93

0.0

Not calculable

Normal weight (18.5-24.9)

658

43.0

34.0

Ref

 

30.6

Ref

 

41.3

Ref

 

41.3

Ref

 

Overweight (25.0-29.9)

509

28.6

34.1

1.72

1.10, 2.71

28.8

1.71

1.13, 2.61

29.6

1.07

0.69, 1.64

33.8

1.13

0.42, 3.05

Mildly Obese (30.0-34.9)

290

20.8

17.0

1.14

0.67, 1.95

19.4

1.38

0.81, 2.36

15.3

0.72

0.41, 1.29

21.5

1.10

0.35, 3.51

Highly Obese (≥35.0)

206

7.6

13.9

2.44

1.24, 4.79

20.0

3.75

1.97, 7.12

13.5

1.97

0.99, 3.89

3.4

0.45

0.11, 1.85

 

Total n

PAM50 Intrinsic Subtype - Premenopausal a,b

 

Luminal A

Luminal B

Basal-like

HER2-E

Normal-like

 

%

%

OR

95% CI

%

OR

95% CI

%

OR

95% CI

%

OR

95% CI

BMI (kg/m 2 )

              

Underweight (<18.5)

5

0.3

2.7

Not calculable

1.6

9.70

1.22, 77.39

1.0

3.83

0.36, 41.95

0.0

Not calculable

Normal weight (18.5-24.9)

179

41.3

40.6

Ref

 

36.3

Ref

 

46.9

Ref

 

19.9

Ref

 

Overweight (25.0-29.9)

112

27.2

33.7

1.77

0.69, 4.52

27.4

1.20

0.52, 2.79

22.3

0.87

0.35, 2.16

26.7

2.96

0.41, 21.51

Mildly Obese (30.0-34.9)

82

22.5

17.0

0.85

0.31, 2.32

20.2

0.74

0.31, 1.79

14.5

0.50

0.18, 1.38

45.4

4.00

0.63, 25.42

Highly Obese (≥35.0)

50

9.0

6.0

0.97

0.21, 4.49

14.5

1.31

0.43, 4.03

15.2

1.92

0.53, 6.96

8.0

2.21

0.28, 17.67

 

Total n

PAM50 Intrinsic Subtype - Postmenopausal a,b

 

Luminal A

Luminal B

Basal-like

HER2-E

Normal-like

 

%

%

OR

95% CI

%

OR

95% CI

%

OR

95% CI

%

OR

95% CI

BMI (kg/m 2 )

              

Underweight (<18.5)

8

0.4

0.2

0.82

0.10, 6.62

1.1

6.97

1.09, 44.38

0.0

Not calculable

0.0

Not calculable

Normal weight (18.5-24.9)

427

41.9

30.9

Ref

 

26.8

Ref

 

39.4

Ref

 

44.1

Ref

 

Overweight (25.0-29.9)

364

29.4

34.4

1.79

1.04, 3.08

29.0

1.94

1.13, 3.34

30.3

1.08

0.65, 1.82

38.6

1.20

0.39, 3.63

Mildly Obese (30.0-34.9)

195

21.6

16.5

1.07

0.56, 2.05

18.8

1.59

0.74, 3.43

16.7

0.77

0.38, 1.56

14.9

0.73

0.19, 2.75

Highly Obese (≥35.0)

141

7.2

18.0

3.10

1.44, 6.68

24.3

6.12

2.81, 13.35

13.6

2.01

0.90, 4.48

2.4

0.29

0.04, 1.83

  1. aFrom multinomial logistic regression with comparison group = Luminal A, adjusted for age at diagnosis, race/ethnicity, moderate-vigorous physical activity, AJCC tumor stage, and study.
  2. bp for interaction=0.52.
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